Metformin‐induced alterations in nucleotide metabolism cause 5‐fluorouracil resistance but gemcitabine susceptibility in oesophageal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26291
Abstract: 5‐Fluorouracil (5‐FU) is a chemotherapeutic agent used to treat a variety of gastric cancers including oesophageal squamous cell carcinoma (OSCC), for which the 5‐year mortality rate exceeds 85%. Our study investigated the effects of metformin,… read more here.
Keywords: gemcitabine; metformin; resistance; nucleotide metabolism ... See more keywords
Effect of decaffeinated coffee on function and nucleotide metabolism in kidney
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DOI: 10.1007/s11010-017-3131-9
Abstract: Little is known about the effects of coffee that are not related to the presence of caffeine. The aim of the study was to analyse changes in kidney function and nucleotide metabolism related to high… read more here.
Keywords: kidney; decaffeinated coffee; function nucleotide; nucleotide metabolism ... See more keywords
Salmonella Reprograms Nucleotide Metabolism in Its Adaptation to Nitrosative Stress
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DOI: 10.1128/mbio.00211-18
Abstract: ABSTRACT The adaptations that protect pathogenic microorganisms against the cytotoxicity of nitric oxide (NO) engendered in the immune response are incompletely understood. We show here that salmonellae experiencing nitrosative stress suffer dramatic losses of the… read more here.
Keywords: stress; nitrosative stress; guanosine tetraphosphate; nucleotide metabolism ... See more keywords
Abstract A41: Nucleotide metabolism heterogeneity in mutant KRAS pancreatic cancer
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DOI: 10.1158/1557-3125.ras18-a41
Abstract: Mutant KRAS orchestrates major metabolic adaptations critical for pancreatic ductal adenocarcinoma (PDAC) growth and survival, including changes in glucose, amino acid, lipid and energy metabolism. However, how nucleotide metabolism in PDAC is impacted by mutant… read more here.
Keywords: pdac; cancer; nucleotide metabolism; pyrimidine ... See more keywords
Identification and characterization of nucleotide metabolism and neuroendocrine regulation-associated modification patterns in stomach adenocarcinoma with auxiliary prognostic assessment and immunotherapy response prediction
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1076521
Abstract: Background The significance of nucleotide metabolism and neuroendocrine in cellular immune response and cancer is becoming more well-established. However, the mechanisms underlying nucleotide metabolism and neuroendocrine involvement in stomach adenocarcinoma (STAD) remain unclear. Methods First,… read more here.
Keywords: nucleotide metabolism; metabolism neuroendocrine; response; modification patterns ... See more keywords
Identification of a nucleotide metabolism-related signature to predict prognosis and guide patient care in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1089291
Abstract: Background: Hepatocellular carcinoma is a highly malignant tumor with significant heterogeneity. Metabolic reprogramming plays an essential role in the progression of hepatocellular carcinoma. Among them, nucleotide metabolism needs further investigation. Methods: Based on the bioinformatics… read more here.
Keywords: nucleotide metabolism; hepatocellular carcinoma; risk score;
Regulation of Adenine Nucleotide Metabolism by Adenylate Kinase Isozymes: Physiological Roles and Diseases
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DOI: 10.3390/ijms24065561
Abstract: Adenylate kinase (AK) regulates adenine nucleotide metabolism and catalyzes the ATP + AMP ⇌ 2ADP reaction in a wide range of organisms and bacteria. AKs regulate adenine nucleotide ratios in different intracellular compartments and maintain… read more here.
Keywords: metabolism; physiological roles; nucleotide metabolism; adenine nucleotide ... See more keywords
PI3K/ c-Myc/AFF4 axis promotes pancreatic tumorigenesis through fueling nucleotide metabolism
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DOI: 10.7150/ijbs.77150
Abstract: MLL-AFF4 fusion gene has been discovered in acute leukemia, whether AFF4 alone plays a role in tumor, especially pancreatic tumorigenesis, is still elusive. Increasing evidence suggests that cancer cells altered nucleotide metabolism during tumorigenesis. In… read more here.
Keywords: nucleotide metabolism; pancreatic tumorigenesis; hprt1 impdh2; aff4 ... See more keywords