MTH1 as a nucleotide pool sanitizing enzyme: Friend or foe?☆
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2016.11.002
Abstract: &NA; 8‐Oxo‐7,8‐dihydroguanine (GO) can originate as 8‐oxo‐7,8‐dihydro‐2′‐deoxyguanosine 5′‐triphosphate (8‐oxo‐dGTP), an oxidized form of dGTP in the nucleotide pool, or by direct oxidation of guanine base in DNA. Accumulation of GO in cellular genomes can result… read more here.
Keywords: accumulation; oxo dgtp; mth1; nucleotide pool ... See more keywords
Structural insights into the specificity and catalytic mechanism of mycobacterial nucleotide pool sanitizing enzyme MutT2.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of structural biology"
DOI: 10.1016/j.jsb.2018.10.002
Abstract: Mis-incorporation of modified nucleotides, such as 5-methyl-dCTP or 8-oxo-dGTP, in DNA can be detrimental to genomic integrity. MutT proteins are sanitization enzymes which function by hydrolyzing such nucleotides and regulating the pool of free nucleotides… read more here.
Keywords: mechanism; pool; mutt2; structural insights ... See more keywords
New insights on the regulation of the adenine nucleotide pool of erythrocytes in mouse models
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DOI: 10.1371/journal.pone.0180948
Abstract: The observation that induced torpor in non-hibernating mammals could result from an increased AMP concentration in circulation led our investigation to reveal that the added AMP altered oxygen transport of erythrocytes. To further study the… read more here.
Keywords: mouse models; adenine nucleotide; amp; nucleotide pool ... See more keywords