Engineering Nucleotide Specificity of Succinyl-CoA Synthetase in Blastocystis: The Emerging Role of Gatekeeper Residues
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DOI: 10.1021/acs.biochem.6b00098
Abstract: Charged, solvent-exposed residues at the entrance to the substrate binding site (gatekeeper residues) produce electrostatic dipole interactions with approaching substrates, and control their access by a novel mechanism called “electrostatic gatekeeper effect”. This proof-of-concept study… read more here.
Keywords: gatekeeper residues; binding site; nucleotide specificity; gatekeeper ... See more keywords