Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3
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DOI: 10.1016/j.celrep.2018.01.076
Abstract: Summary Sirtuin 3 (SIRT3) is a NAD+-dependent deacetylase downregulated in aging and age-associated diseases such as cancer and neurodegeneration and in high-fat diet (HFD)-induced metabolic disorders. Here, we performed a small-molecule screen and identified an… read more here.
Keywords: molecule screen; novo nucleotide; small molecule; nucleotide synthesis ... See more keywords
Chemistry of Abiotic Nucleotide Synthesis.
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DOI: 10.1021/acs.chemrev.9b00546
Abstract: The chemistry of abiotic nucleotide synthesis of RNA and DNA in the context of their prebiotic origins on early earth is a continuing challenge. How did (or how can) the nucleotides form and assemble from… read more here.
Keywords: abiotic nucleotide; synthesis; chemistry; nucleotide synthesis ... See more keywords
Metabolic Profiling Identifies De Novo Nucleotide Synthesis As a Potential Metabolic Vulnerability for Targeted Therapy Against Mantle Cell Lymphoma
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DOI: 10.1182/blood-2018-99-112192
Abstract: Introduction: Cancer cells exhibit dramatic alterations in cellular metabolism, such as enhanced de novo nucleotide synthesis, to support cell growth, proliferation and survival. The abundance of the nucleotide pool as well as the level and… read more here.
Keywords: subset mcl; novo nucleotide; nucleotide synthesis; cell ... See more keywords