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Published in 2022 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.13510
Abstract: Degeneration of the nucleus basalis of Meynert (NBM) and cortical cholinergic dysfunction are hallmarks of Parkinson's disease dementia (PDD). There is no effective therapy for PDD. Deep brain stimulation of the NBM (NBM‐DBS) has been…
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Keywords:
basalis meynert;
disease dementia;
parkinson disease;
deep brain ... See more keywords
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Published in 2020 at "Brain"
DOI: 10.1093/brain/awaa411
Abstract: Abstract Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) are related conditions that are associated with cholinergic system dysfunction. Dysfunction of the nucleus basalis of Meynert (NBM), a basal forebrain structure that provides…
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Keywords:
connectivity;
basalis meynert;
nucleus basalis;
disease ... See more keywords
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Published in 2022 at "Brain"
DOI: 10.1093/brain/awac093
Abstract: Abstract Cognitive deficits in Alzheimer’s disease, specifically amnestic (memory dominant) deficits, are associated with cholinergic degeneration in the basal forebrain. The cholinergic nucleus within the basal forebrain, the nucleus basalis of Meynert, exhibits local atrophy…
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Keywords:
basalis meynert;
cholinergic cell;
disease;
alzheimer disease ... See more keywords
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Published in 2017 at "Cerebral Cortex"
DOI: 10.1093/cercor/bhw195
Abstract: Extensive research suggests that basal forebrain (BF) cholinergic neurons are selectively vulnerable to Alzheimer's disease (AD). However, it remains unknown whether volume loss of BF cholinergic compartments parallels structural changes of their innervated regions in…
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Keywords:
innervated regions;
volume;
nucleus basalis;
cognitive impairment ... See more keywords
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Published in 2022 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.15642
Abstract: Storage of aversive memories is of utmost importance for survival, allowing animals to avoid upcoming similar stimuli. However, without reinforcement, the learned avoidance response gradually decreases over time. Although the molecular mechanisms controlling this extinction…
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Keywords:
response;
gentle handling;
nucleus basalis;
novel object ... See more keywords
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Published in 2018 at "Radiology"
DOI: 10.1148/radiol.2018180092
Abstract: Purpose To determine whether functional connectivity (FC) mapping of nucleus basalis of Meynert (NBM) cholinergic network (hereafter, NBM FC) could provide a biomarker of central cholinergic deficits with predictive potential for response to cholinesterase inhibitor…
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Keywords:
treatment;
nucleus basalis;
nbm;
cognitive impairment ... See more keywords
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Published in 2022 at "eNeuro"
DOI: 10.1523/eneuro.0164-22.2022
Abstract: Abstract Nucleus basalis magnocellularis (NBM) cholinergic projections to the basolateral amygdala (BLA) regulate the acquisition and consolidation of fear-like and anxiety-like behaviors. However, it is unclear whether the alterations in the NBM-BLA circuit promote negative…
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Keywords:
withdrawal;
ethanol;
nucleus basalis;
basalis magnocellularis ... See more keywords
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Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.851788
Abstract: Objectives To study in vivo gray matter (GM) volumes of the nucleus basalis of Meynert (nbM) in different parkinsonian syndromes and assess their relationship with clinical variables. Methods T1-weighted magnetic resonance images from patients with…
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Keywords:
basalis meynert;
progressive supranuclear;
nbm volumes;
parkinson disease ... See more keywords