Deep Brain Stimulation of the Nucleus Basalis of Meynert for Parkinson's Disease Dementia: A 36 Months Follow Up Study
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.13510
Abstract: Degeneration of the nucleus basalis of Meynert (NBM) and cortical cholinergic dysfunction are hallmarks of Parkinson's disease dementia (PDD). There is no effective therapy for PDD. Deep brain stimulation of the NBM (NBM‐DBS) has been… read more here.
Keywords: basalis meynert; disease dementia; parkinson disease; deep brain ... See more keywords
Cortical connectivity of the nucleus basalis of Meynert in Parkinson’s disease and Lewy body dementias
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DOI: 10.1093/brain/awaa411
Abstract: Abstract Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) are related conditions that are associated with cholinergic system dysfunction. Dysfunction of the nucleus basalis of Meynert (NBM), a basal forebrain structure that provides… read more here.
Keywords: connectivity; basalis meynert; nucleus basalis; disease ... See more keywords
Structural (dys)connectivity associates with cholinergic cell density in Alzheimer’s disease
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DOI: 10.1093/brain/awac093
Abstract: Abstract Cognitive deficits in Alzheimer’s disease, specifically amnestic (memory dominant) deficits, are associated with cholinergic degeneration in the basal forebrain. The cholinergic nucleus within the basal forebrain, the nucleus basalis of Meynert, exhibits local atrophy… read more here.
Keywords: basalis meynert; cholinergic cell; disease; alzheimer disease ... See more keywords
Volume Loss of the Nucleus Basalis of Meynert is Associated with Atrophy of Innervated Regions in Mild Cognitive Impairment
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DOI: 10.1093/cercor/bhw195
Abstract: Extensive research suggests that basal forebrain (BF) cholinergic neurons are selectively vulnerable to Alzheimer's disease (AD). However, it remains unknown whether volume loss of BF cholinergic compartments parallels structural changes of their innervated regions in… read more here.
Keywords: innervated regions; volume; nucleus basalis; cognitive impairment ... See more keywords
Handling and novel object recognition modulate fear response and endocannabinoid signaling in nucleus basalis magnocellularis
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DOI: 10.1111/ejn.15642
Abstract: Storage of aversive memories is of utmost importance for survival, allowing animals to avoid upcoming similar stimuli. However, without reinforcement, the learned avoidance response gradually decreases over time. Although the molecular mechanisms controlling this extinction… read more here.
Keywords: response; gentle handling; nucleus basalis; novel object ... See more keywords
Altered Nucleus Basalis Connectivity Predicts Treatment Response in Mild Cognitive Impairment
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DOI: 10.1148/radiol.2018180092
Abstract: Purpose To determine whether functional connectivity (FC) mapping of nucleus basalis of Meynert (NBM) cholinergic network (hereafter, NBM FC) could provide a biomarker of central cholinergic deficits with predictive potential for response to cholinesterase inhibitor… read more here.
Keywords: treatment; nucleus basalis; nbm; cognitive impairment ... See more keywords
Chronic Intermittent Ethanol Exposure Dysregulates Nucleus Basalis Magnocellularis Afferents in the Basolateral Amygdala
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DOI: 10.1523/eneuro.0164-22.2022
Abstract: Abstract Nucleus basalis magnocellularis (NBM) cholinergic projections to the basolateral amygdala (BLA) regulate the acquisition and consolidation of fear-like and anxiety-like behaviors. However, it is unclear whether the alterations in the NBM-BLA circuit promote negative… read more here.
Keywords: withdrawal; ethanol; nucleus basalis; basalis magnocellularis ... See more keywords
Reduction in Volume of Nucleus Basalis of Meynert Is Specific to Parkinson’s Disease and Progressive Supranuclear Palsy but Not to Multiple System Atrophy
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DOI: 10.3389/fnagi.2022.851788
Abstract: Objectives To study in vivo gray matter (GM) volumes of the nucleus basalis of Meynert (nbM) in different parkinsonian syndromes and assess their relationship with clinical variables. Methods T1-weighted magnetic resonance images from patients with… read more here.
Keywords: basalis meynert; progressive supranuclear; nbm volumes; parkinson disease ... See more keywords
The role of the nucleus basalis of Meynert in neuromodulation therapy: a systematic review from the perspective of neural network oscillations
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DOI: 10.3389/fnagi.2024.1376764
Abstract: As a crucial component of the cerebral cholinergic system and the Papez circuit in the basal forebrain, dysfunction of the nucleus basalis of Meynert (NBM) is associated with various neurodegenerative disorders. However, no drugs, including… read more here.
Keywords: neuromodulation; basalis meynert; nucleus basalis; network oscillations ... See more keywords
Free-water imaging of the nucleus basalis of Meynert in apolipoprotein E4 carriers
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DOI: 10.3389/fnagi.2025.1597127
Abstract: Introduction The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD) and cardiovascular disease. This study aimed to investigate the interactive effects of APOE ε4 genotype and cardiovascular… read more here.
Keywords: basalis meynert; free water; risk; nucleus basalis ... See more keywords
Increased free water in the nucleus basalis of Meynert is associated with worse olfaction in idiopathic Parkinson’s disease
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DOI: 10.3389/fnagi.2025.1689150
Abstract: Background The association of cholinergic degeneration and olfactory function in Parkinson’s disease (PD) is unclear. Using free water imaging, this study aims to investigate the association between the nucleus basalis of Meynert (NBM) degeneration and… read more here.
Keywords: basalis meynert; water; free water; nucleus basalis ... See more keywords