The DNA damage response promotes polyomavirus JC infection by nucleus to cytoplasm NF- kappaB activation
Sign Up to like & getrecommendations! Published in 2017 at "Virology Journal"
DOI: 10.1186/s12985-017-0707-7
Abstract: BackgroundInfection of glial cells by human neurotropic polyomavirus JC (JCV), the causative agent of the CNS demyelinating disease progressive multifocal leukoencephalopathy (PML), rapidly inflicts damage to cellular DNA. This activates DNA damage response (DDR) signaling… read more here.
Keywords: dna; infection; jcv infection; jcv ... See more keywords
An image-based flow cytometric approach to the assessment of the nucleus-to-cytoplasm ratio
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DOI: 10.1371/journal.pone.0253439
Abstract: The nucleus-to-cytoplasm ratio (N:C) can be used as one metric in histology for grading certain types of tumor malignancy. Current N:C assessment techniques are time-consuming and low throughput. Thus, in high-throughput clinical contexts, there is… read more here.
Keywords: cytoplasm ratio; ratio; malignant cell; cancer ... See more keywords