Metabolism Balance Regulation via Antagonist‐Functionalized Injectable Microsphere for Nucleus Pulposus Regeneration
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202006333
Abstract: Antagonist therapy represents a potential treatment for extracellular matrix (ECM) metabolic imbalance via the specific binding of inflammatory factors resulting from inflammation. However, the short half‐life of antagonist bioactivity creates challenges for their clinical application.… read more here.
Keywords: antagonist functionalized; functionalized injectable; antagonist; balance ... See more keywords
Circadian clock regulation via biomaterials for nucleus pulposus.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202301037
Abstract: Circadian clock disorder during tissue degeneration has been considered the potential pathogenesis for various chronic diseases, such as intervertebral disc degeneration (IVDD). In this study, circadian clock-regulating biomaterials (ClockMPs) that could effectively activate the intrinsic… read more here.
Keywords: circadian clock; clockmps could; clock regulation; nucleus pulposus ... See more keywords
Discovery and Application of Postnatal Nucleus Pulposus Progenitors Essential for Intervertebral Disc Homeostasis and Degeneration.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced science"
DOI: 10.1002/advs.202104888
Abstract: Intervertebral disc degeneration (IDD) results from the dysfunction of nucleus pulposus (NP) cells and the exhaustion of NP progenitors (ProNPs). The cellular applications of NP cells during IDD are currently limited due to the lack… read more here.
Keywords: pronps; degeneration; nucleus pulposus; intervertebral disc ... See more keywords
PTEN promotes intervertebral disc degeneration by regulating nucleus pulposus cell behaviors
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology International"
DOI: 10.1002/cbin.11258
Abstract: Intervertebral disc degeneration (IDD) is induced by multiple factors including increased apoptosis, decreased survival, and reduced extracellular matrix (ECM) synthesis in the nucleus pulposus (NP) cells. The tumor suppressor phosphatase and tensin homolog deleted from… read more here.
Keywords: disc; pi3k akt; intervertebral disc; nucleus pulposus ... See more keywords
α‐Mangostin protects lipopolysaccharide‐stimulated nucleus pulposus cells against NLRP3 inflammasome‐mediated apoptosis via the NF‐κB pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4306
Abstract: Intervertebral disc degeneration (IDD) is a common and chronic inflammatory disorder. α‐Mangostin exhibits a novel biological function against inflammation in various inflammatory diseases. Here, we aimed to explore the role of α‐mangostin in IDD using… read more here.
Keywords: apoptosis; expression; mangostin; nucleus pulposus ... See more keywords
The inflammatory cytokine TNF‐α regulates the biological behavior of rat nucleus pulposus mesenchymal stem cells through the NF‐κB signaling pathway in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28640
Abstract: Nucleus pulposus (NP) mesenchymal stem cells (NPMSCs) are a potential cell source for intervertebral disc (IVD) regeneration; however, little is known about their response to tumor necrosis factor‐α (TNF‐α), a critical inflammation factor contributing to… read more here.
Keywords: tnf; differentiation; nucleus pulposus; pulposus mesenchymal ... See more keywords
High amplitude and low frequency cyclic mechanical strain promotes degeneration of human nucleus pulposus cells via the NF‐κB p65 pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26551
Abstract: Disc degeneration alters the structure and function of intervertebral discs and is the basis of spinal degenerative diseases. To establish the molecular mechanism of intervertebral disc degeneration caused by mechanical strain, this study examined the… read more here.
Keywords: human nucleus; cms; pulposus cells; pulposus ... See more keywords
lncRNA HOTAIR upregulates autophagy to promote apoptosis and senescence of nucleus pulposus cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29129
Abstract: Intervertebral disc degeneration (IDD) is a complex and chronic disease that involves disc cell senescence, death, and extracellular matrix (ECM) degradation. HOTAIR, a long non‐coding RNA (lncRNA) is reportedly associated with autophagy, whereas autophagy is… read more here.
Keywords: apoptosis senescence; hotair; senescence; pulposus cells ... See more keywords
Inorganic polyphosphates enhances nucleus pulposus tissue formation in vitro
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DOI: 10.1002/jor.23288
Abstract: Disc degeneration is associated with low back pain for which currently there is no optimal therapy so there is a great need to identify new treatment approaches. Inorganic polyphosphates (polyP) are linear polymers of orthophosphate… read more here.
Keywords: inorganic polyphosphates; tissue formation; formation vitro; treatment ... See more keywords
Collateral effects of targeting the nucleus pulposus via a transpedicular or transannular surgical route: a combined X-ray, MRI, and histological long-term descriptive study in sheep
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DOI: 10.1007/s00586-020-06602-5
Abstract: Purpose In the context of regenerative medicine strategies, based in particular on the injection of regenerative cells, biological factors, or biomaterials into the nucleus pulposus (NP), two main routes are used: the transpedicular approach (TPA)… read more here.
Keywords: medicine; long term; study; nucleus pulposus ... See more keywords
Baicalein Inhibits the IL-1β-Induced Inflammatory Response in Nucleus Pulposus Cells and Attenuates Disc Degeneration In vivo
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DOI: 10.1007/s10753-019-00965-8
Abstract: Intervertebral disc degeneration (IDD) is widely considered one of the main causes of low back pain, which is a chronic progressive disease closely related to inflammation and degeneration of nucleus pulposus (NP) cells. Baicalein is… read more here.
Keywords: inflammatory response; degeneration; pulposus cells; nucleus pulposus ... See more keywords