The hindbrain is a site of energy balance action for prolactin-releasing peptide: feeding and thermic effects from GPR10 stimulation of the nucleus tractus solitarius/area postrema
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DOI: 10.1007/s00213-018-4925-5
Abstract: PurposeProlactin-releasing peptide (PrRP) is a neuropeptide that suppresses food intake and increases body temperature when delivered to the forebrain ventricularly or parenchymally. However, PrRP’s receptor GPR10 is widely distributed throughout the brain with particularly high… read more here.
Keywords: releasing peptide; prrp; nucleus tractus; area postrema ... See more keywords
Acute ethanol modulation of neurocircuit function in the nucleus of the tractus solitarius
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DOI: 10.1016/j.brainresbull.2017.07.019
Abstract: The nucleus of the tractus solitarius (NTS) is a brain stem region critical to many physiologic processes and has been implicated in addiction to multiple classes of abused drugs, including alcohol (EtOH). That said, the… read more here.
Keywords: nucleus tractus; etoh; mechanism; tractus solitarius ... See more keywords
Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome
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DOI: 10.1016/j.nbd.2017.09.006
Abstract: Rett syndrome (RTT) is a devastating neurodevelopmental disorder caused by loss-of-function mutations in the X-linked methyl-CpG binding protein 2 (Mecp2) gene. GABAergic dysfunction has been implicated contributing to the respiratory dysfunction, one major clinical feature… read more here.
Keywords: null mice; nucleus tractus; rett syndrome; mecp2 null ... See more keywords
Endogenous Glucagon-like Peptide-1 Receptor Signaling in the Nucleus Tractus Solitarius is Required for Food Intake Control
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DOI: 10.1038/npp.2016.246
Abstract: Alhough the glucagon-like peptide-1 (GLP-1) system is critical to energy balance control and is a target for obesity pharmacotherapies, the receptor-population-mediating effects of endogenous GLP-1 signaling are not fully understood. To address this, we developed… read more here.
Keywords: glucagon like; glp; control; nucleus tractus ... See more keywords
Cardiovascular deconditioning increases GABA signaling in the nucleus tractus solitarii.
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DOI: 10.1152/jn.00102.2022
Abstract: The nucleus tractus solitarii (nTS) is the major integrative brainstem region for autonomic modulation and processing of cardiovascular reflexes. GABA and glutamate are the main inhibitory and excitatory neurotransmitters, respectively, within this nucleus. Alterations in… read more here.
Keywords: nucleus tractus; tractus solitarii; gaba signaling; cardiovascular deconditioning ... See more keywords
Neuroanatomical and neurophysiological evidence of pulmonary nociceptor and carotid chemoreceptor convergence in the nucleus tractus solitarius and nucleus ambiguus
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DOI: 10.1152/jn.00125.2022
Abstract: Pulmonary vagal nociceptors defend the airways. Cardiopulmonary vagal nociceptors synapse in the nucleus tractus solitarius (NTS). Evidence has demonstrated convergence of cardiopulmonary nociceptors with afferents from carotid chemoreceptors. Whether sensory convergence occurs in motor nuclei… read more here.
Keywords: nucleus tractus; solitarius nucleus; convergence; nucleus ambiguus ... See more keywords
Altered A-type potassium channel function in the nucleus tractus solitarii in acquired temporal lobe epilepsy.
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DOI: 10.1152/jn.00556.2018
Abstract: Sudden unexpected death in epilepsy (SUDEP) is among the leading causes of death in people with epilepsy. Individuals with temporal lobe epilepsy (TLE) have a high risk for SUDEP because the seizures are often medically… read more here.
Keywords: epilepsy; nucleus tractus; excitability; tractus solitarii ... See more keywords
Involvement of the cAMP-Dependent Pathway in Dextromethorphan-Induced Inhibition of Spontaneous Glutamate Transmission in the Nucleus Tractus Solitarius Neurons of Guinea Pigs
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DOI: 10.1159/000495295
Abstract: Dextromethorphan (DEX) presynaptically decreases glutamatergic transmission in second-order neurons of the nucleus tractus solitarius (TS). To clarify the inhibitory mechanism of DEX, the present study examined the interaction of DEX with cAMP. The effects of… read more here.
Keywords: camp; dex; dependent pathway; nucleus tractus ... See more keywords
Teaching NeuroImage: Bilateral Nucleus Tractus Solitarius Lesions in Neurogenic Respiratory Failure
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DOI: 10.1212/wnl.0000000000012614
Abstract: A 7-year-old girl with MEGD(H)EL [3-methylglutaconic aciduria, dystonia-deafness, (hepatopathy), encephalopathy, Leigh-like syndrome, SERAC1]1 presented with worsening respiratory compromise. The evaluation showed type II respiratory failure (e.g., hypercapnic) necessitating mechanical ventilation. Cerebral MRI demonstrated progression of… read more here.
Keywords: respiratory failure; tractus solitarius; nucleus tractus;
Hyperglycemia Induced by Chronic Restraint Stress in Mice Is Associated With Nucleus Tractus Solitarius Injury and Not Just the Direct Effect of Glucocorticoids
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DOI: 10.3389/fnins.2018.00983
Abstract: Chronic restraint stress (CRS) can affect hypothalamic-pituitary-adrenal (HPA) axis activity and increase glucocorticoid levels. Glucocorticoids are stress hormones that regulate multiple aspects of energy homeostasis. Stress also impairs glucose tolerance. The aim of this study… read more here.
Keywords: nucleus tractus; stress; restraint stress; hyperglycemia ... See more keywords
Investigation of the Role of AT2 Receptors in the Nucleus Tractus Solitarii of Normotensive Rats in Blood Pressure Control
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DOI: 10.3389/fnins.2019.00589
Abstract: Aim The nucleus tractus solitarii (NTS) densely expresses angiotensin II type 2 receptors (AT2R), which are mainly located on inhibitory gamma-aminobutyric acid (GABA) neurons. Central AT2R stimulation reduces blood pressure, and AT2R stimulation in the… read more here.
Keywords: nucleus tractus; blood pressure; gaba; tractus solitarii ... See more keywords