Single nucleus transcriptomics, pharmacokinetics, and pharmacodynamics of CDK4/6 and mTOR inhibition in a phase 0/1 trial of recurrent high-grade glioma.
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaf257
Abstract: BACKGROUND Outcomes for adult patients with high-grade glioma (HGG) remain poor, necessitating new treatment strategies. Key challenges include poor drug penetration in the brain and malignant cell state plasticity. Phase 0 studies identify agents that… read more here.
Keywords: malignant cell; trial; pharmacokinetics pharmacodynamics; cell ... See more keywords
Single-nucleus transcriptomics reveals sepsis-related neurovascular dysfunction in the human hippocampus
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1648278
Abstract: Introduction Sepsis is increasingly recognized as a major precipitant of long-term cognitive impairment, yet the cellular mechanisms underlying hippocampal vulnerability remain elusive. Methods We performed single-nucleus RNA sequencing of human hippocampal tissues from sepsis and… read more here.
Keywords: hippocampus; astrocyte; transcriptomics reveals; nucleus transcriptomics ... See more keywords
Single-Nucleus Transcriptomics Reveals Glial Metabolic–Immune Rewiring and Intercellular Signaling Disruption in Chronic Migraine
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DOI: 10.3390/biom15070942
Abstract: Chronic migraine (CM) is a debilitating neurological disorder, yet the glial-specific mechanisms underlying its pathophysiology in the trigeminal nucleus caudalis (TNC)—a critical hub for craniofacial pain processing—remain poorly understood. Here, we employed single-nucleus RNA sequencing… read more here.
Keywords: chronic migraine; metabolic immune; single nucleus; nucleus transcriptomics ... See more keywords