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Published in 2018 at "Medicine"
DOI: 10.1097/md.0000000000010301
Abstract: Introduction: Azathioprine (AZA) is widely used as an immunosuppressive agent, and its efficacy has been recommended by many clinical studies. However, leukopenia, the most common toxicity, still restricts its clinical applications. Recent studies found that…
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Keywords:
azathioprine;
nudt15 r139c;
toxicity;
induced toxicity ... See more keywords
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Published in 2018 at "OncoTargets and therapy"
DOI: 10.2147/ott.s177007
Abstract: Background and aim Despite several studies being conducted to examine the associations between the NUDT15 R139C polymorphism and thiopurine-induced leukopenia in the Asian population, the results remain inconsistent. This meta-analysis determined the risk of thiopurine-induced…
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Keywords:
r139c polymorphism;
thiopurine induced;
nudt15 r139c;
model ... See more keywords
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Published in 2019 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v25.i38.5850
Abstract: BACKGROUND Thiopurine-induced leukopenia (TIL) is a life-threatening toxicity and occurs with a high frequency in the Asian population. Although nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) variants significantly improve the predictive sensitivity of TIL, more…
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Keywords:
cut levels;
r139c genotypes;
pmol 108;
nudt15 r139c ... See more keywords