NUDT15 R139C variation increases the risk of azathioprine-induced toxicity in Chinese subjects
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DOI: 10.1097/md.0000000000010301
Abstract: Introduction: Azathioprine (AZA) is widely used as an immunosuppressive agent, and its efficacy has been recommended by many clinical studies. However, leukopenia, the most common toxicity, still restricts its clinical applications. Recent studies found that… read more here.
Keywords: azathioprine; nudt15 r139c; toxicity; induced toxicity ... See more keywords
Associations between the NUDT15 R139C polymorphism and susceptibility to thiopurine-induced leukopenia in Asians: a meta-analysis
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DOI: 10.2147/ott.s177007
Abstract: Background and aim Despite several studies being conducted to examine the associations between the NUDT15 R139C polymorphism and thiopurine-induced leukopenia in the Asian population, the results remain inconsistent. This meta-analysis determined the risk of thiopurine-induced… read more here.
Keywords: r139c polymorphism; thiopurine induced; nudt15 r139c; model ... See more keywords
Nucleoside diphosphate-linked moiety X-type motif 15 R139C genotypes impact 6-thioguanine nucleotide cut-off levels to predict thiopurine-induced leukopenia in Crohn’s disease patients
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DOI: 10.3748/wjg.v25.i38.5850
Abstract: BACKGROUND Thiopurine-induced leukopenia (TIL) is a life-threatening toxicity and occurs with a high frequency in the Asian population. Although nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) variants significantly improve the predictive sensitivity of TIL, more… read more here.
Keywords: cut levels; r139c genotypes; pmol 108; nudt15 r139c ... See more keywords