Neurogranin Regulates Alcohol Sensitivity through AKT Pathway in the Nucleus Accumbens
Sign Up to like & getrecommendations! Published in 2019 at "PROTEOMICS"
DOI: 10.1002/pmic.201900266
Abstract: Dysfunction of glutamate neurotransmission in the nucleus accumbens (NAc) has been implicated in the pathophysiology of alcohol use disorders (AUD). Neurogranin (Ng) is exclusively expressed in the brain and mediates N‐methyl‐d‐aspartate receptor (NMDAR) hypo‐function by… read more here.
Keywords: null mice; alcohol sensitivity; nucleus accumbens; mice ... See more keywords
Inhibition of osteoclast differentiation and collagen antibody-induced arthritis by CTHRC1.
Sign Up to like & getrecommendations! Published in 2017 at "Bone"
DOI: 10.1016/j.bone.2017.01.022
Abstract: Collagen triple helix repeat-containing1 (Cthrc1) has previously been implicated in osteogenic differentiation and positive regulation of bone mass, however, the underlying mechanisms remain unclear. Here we characterized the bone phenotype of a novel Cthrc1 null… read more here.
Keywords: null mice; cthrc1; bone; differentiation ... See more keywords
Dcf1 deficiency induces hypomyelination by activating Wnt signaling
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2020.113486
Abstract: Myelination is extremely important in achieving neural function. Hypomyelination causes a variety of neurological diseases. However, little is known about how hypomyelination occurs. Here we investigated the effect of dendritic cell factor 1(Dcf1) on myelination,… read more here.
Keywords: null mice; dcf1; hypomyelination; myelination ... See more keywords
Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2017.09.006
Abstract: Rett syndrome (RTT) is a devastating neurodevelopmental disorder caused by loss-of-function mutations in the X-linked methyl-CpG binding protein 2 (Mecp2) gene. GABAergic dysfunction has been implicated contributing to the respiratory dysfunction, one major clinical feature… read more here.
Keywords: null mice; nucleus tractus; rett syndrome; mecp2 null ... See more keywords
Hepatic carboxylesterases are differentially regulated in PPARα-null mice treated with perfluorooctanoic acid.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology"
DOI: 10.1016/j.tox.2019.01.014
Abstract: Hepatic carboxylesterases (Ces) catalyze the metabolism of drugs, environmental toxicants, and endogenous lipids and are known to be regulated by multiple nuclear receptors. Perfluorooctanoic acid (PFOA) is a synthetic fluorochemical that has been associated with… read more here.
Keywords: null mice; pfoa; hepatic carboxylesterases; mice ... See more keywords
Targeted Metabolomics Reveals a Protective Role for Basal PPARα in Cholestasis Induced by α-Naphthylisothiocyanate.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.7b00838
Abstract: α-Naphthylisothiocyanate (ANIT) is an experimental agent used to induce intrahepatic cholestasis. The Ppara-null mouse line is widely employed to explore the physiological and pathological roles of PPARα. However, little is known about how PPARα influences… read more here.
Keywords: null mice; ppara null; mice; basal ppar ... See more keywords
Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14577
Abstract: NF-E2-related factor-2 (Nrf2) regulates cellular responses to oxidative and electrophilic stress. Loss of Keap1 increases Nrf2 protein levels, and Keap1-null mice die of oesophageal hyperkeratosis because of Nrf2 hyperactivation. Here we show that deletion of… read more here.
Keywords: null mice; hyperactivation; keap1 null; nephrogenic diabetes ... See more keywords
A2A Receptor Contributes to Tumor Progression in P2X7 Null Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.1101/2022.02.28.482298
Abstract: ATP and adenosine are key constituents of the tumor niche where they exert opposite and complementary roles. ATP promotes tumor growth but also immune eradicating responses mainly via the P2X7 receptor (P2X7R), while adenosine acts… read more here.
Keywords: null mice; receptor; tumor; p2x7 null ... See more keywords
Neonatal Scn1b-null mice have sinoatrial node dysfunction, altered atrial structure, and atrial fibrillation
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.152050
Abstract: Loss-of-function (LOF) variants in SCN1B, encoding the voltage-gated sodium channel β1/β1B subunits, are linked to neurological and cardiovascular diseases. Scn1b-null mice have spontaneous seizures and ventricular arrhythmias and die by approximately 21 days after birth.… read more here.
Keywords: null mice; physiology; dysfunction; scn1b null ... See more keywords
Loss of IκBζ Drives Dentin Formation via Altered H3K4me3 Status
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Dental Research"
DOI: 10.1177/00220345221075968
Abstract: Enforced enrichment of the active promoter marks trimethylation of histone H3 lysine 4 (H3K4me3) and acetylation of histone H3 lysine 27 (H3K27ac) by inhibiting histone demethylases and deacetylases is positively associated with hard tissue formation… read more here.
Keywords: status; formation; null mice; dentin ... See more keywords
Mass spectrometry imaging and LC/MS reveal decreased cerebellar phosphoinositides in Niemann-Pick type C1-null mice[S]
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Lipid Research"
DOI: 10.1194/jlr.ra119000606
Abstract: Niemann-Pick disease type C1 (NPC1) is a lipid storage disorder in which cholesterol and glycosphingolipids accumulate in late endosomal/lysosomal compartments because of mutations in the NPC1 gene. A hallmark of NPC1 is progressive neurodegeneration of… read more here.
Keywords: null mice; npc1 null; mass spectrometry; mice ... See more keywords