Regulation of Hox and ParaHox Genes by Perfluorochemicals in Mouse Liver.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology"
DOI: 10.1016/j.tox.2020.152521
Abstract: Homeobox (Hox) genes encode homeodomain proteins, which play important roles in the development and morphological diversification of organisms including plants and animals. Perfluorinated chemicals (PFCs), which are well recognized industrial pollutants and universally detected in… read more here.
Keywords: mouse livers; null mouse; hox; mrna expression ... See more keywords
LIN28A binds to meiotic gene transcripts and modulates their translation in male germ cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.242701
Abstract: ABSTRACT The RNA-binding protein LIN28A is required for maintaining tissue homeostasis, including in the reproductive system, but the underlying mechanisms on how LIN28A regulates germline progenitors remain unclear. Here, we dissected LIN28A-binding targets using high-throughput… read more here.
Keywords: mouse testes; lin28a binds; null mouse; translation ... See more keywords
Mixed Neurodevelopmental and Neurodegenerative Pathology in Nhe6-Null Mouse Model of Christianson Syndrome
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DOI: 10.1523/eneuro.0388-17.2017
Abstract: Abstract Christianson syndrome (CS) is an X-linked disorder resulting from loss-of-function mutations in SLC9A6, which encodes the endosomal Na+/H+ exchanger 6 (NHE6). Symptoms include early developmental delay, seizures, intellectual disability, nonverbal status, autistic features, postnatal… read more here.
Keywords: neurodegenerative pathology; christianson syndrome; pathology; nhe6 null ... See more keywords
The microRNA-455 Null Mouse Has Memory Deficit and Increased Anxiety, Targeting Key Genes Involved in Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23010554
Abstract: The complete molecular mechanisms underlying the pathophysiology of Alzheimer’s disease (AD) remain to be elucidated. Recently, microRNA-455-3p has been identified as a circulating biomarker of early AD, with increased expression in post-mortem brain tissue of… read more here.
Keywords: null mouse; microrna 455; 455 null; mir 455 ... See more keywords