Critical Role for Saccharomyces cerevisiae Asc1p in Translational Initiation at Elevated Temperatures
Sign Up to like & getrecommendations! Published in 2018 at "PROTEOMICS"
DOI: 10.1002/pmic.201800208
Abstract: The eukaryotic ribosomal protein RACK1/Asc1p is localized to the mRNA exit channel of the 40S subunit but lacks a defined role in mRNA translation. Saccharomyces cerevisiae deficient in ASC1 exhibit temperature‐sensitive growth. Using this null… read more here.
Keywords: saccharomyces cerevisiae; role saccharomyces; critical role; translation ... See more keywords
An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx811
Abstract: Abstract Mouse embryonic stem (ES) cells are a popular model system to study biological processes, though uncovering recessive phenotypes requires inactivating both alleles. Building upon resources from the International Knockout Mouse Consortium (IKMC), we developed… read more here.
Keywords: mouse embryonic; mutant mouse; embryonic stem; null mutant ... See more keywords
Hypoviral‐regulated HSP90 co‐chaperone p23 (CpCop23) determines the colony morphology, virulence, and viral response of chestnut blight fungus Cryphonectria parasitica
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Plant Pathology"
DOI: 10.1111/mpp.13308
Abstract: Abstract We previously identified a protein spot that showed down‐regulation in the presence of Cryphonectria hypovirus 1 (CHV1) and tannic acid supplementation as a Hsp90 co‐chaperone p23 gene (CpCop23). The CpCop23‐null mutant strain showed retarded… read more here.
Keywords: null mutant; hsp90; mutant; virulence ... See more keywords
Comparative proteomic analysis of Neisseria meningitidis wildtype and dprA null mutant strains links DNA processing to pilus biogenesis
Sign Up to like & getrecommendations! Published in 2017 at "BMC Microbiology"
DOI: 10.1186/s12866-017-1004-8
Abstract: BackgroundDNA processing chain A (DprA) is a DNA binding protein which is ubiquitous in bacteria, and is required for DNA transformation to various extents among bacterial species. However, the interaction of DprA with competence and… read more here.
Keywords: dna; dpra; dpra null; pilus biogenesis ... See more keywords
Reduced Dynamin-I levels in neurons lacking MUNC18-1.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cell science"
DOI: 10.1242/jcs.260132
Abstract: MUNC18-1/Syntaxin binding protein-1 (Stxbp1), binds Syntaxin-1. Together, these proteins regulate synaptic vesicle exocytosis and have a separate role in neuronal viability. In MUNC18-1/Stxbp1 null mutant neurons, Syntaxin-1 protein levels are 70% reduced. Here, we show… read more here.
Keywords: null mutant; stxbp1 null; munc18; neurons lacking ... See more keywords
Construction of a fur null mutant and RNA-sequencing provide deeper global understanding of the Aliivibrio salmonicida Fur regulon
Sign Up to like & getrecommendations! Published in 2017 at "PeerJ"
DOI: 10.7717/peerj.3461
Abstract: Background The ferric uptake regulator (Fur) is a transcription factor and the main regulator of iron acquisition in prokaryotes. When bound to ferric iron, Fur recognizes its DNA binding site and generally executes its function… read more here.
Keywords: fur null; iron; null mutant; fur ... See more keywords