Genome‐wide analysis of colorectal cancer based on gene‐based somatic copy number alterations during neoplastic progression within the same tumor
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5117
Abstract: The objective of this study was to elucidate the association between neoplastic progression and somatic copy number alterations (SCNAs) occurring within the same colorectal cancer (CRC) tumor. read more here.
Keywords: number alterations; somatic copy; neoplastic progression; colorectal cancer ... See more keywords
Convergent Evolution of Copy Number Alterations in Multi-Centric Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-40843-9
Abstract: In the recent years, new molecular methods have been proposed to discriminate multicentric hepatocellular carcinomas (HCC) from intrahepatic metastases. Some of these methods utilize sequencing data to assess similarities between cancer genomes, whilst other achieved… read more here.
Keywords: multi centric; copy number; convergent evolution; number alterations ... See more keywords
Refinement of computational identification of somatic copy number alterations using DNA methylation microarrays illustrated in cancers of unknown primary
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbac161
Abstract: Abstract High-throughput genomic technologies are increasingly used in personalized cancer medicine. However, computational tools to maximize the use of scarce tissues combining distinct molecular layers are needed. Here we present a refined strategy, based on… read more here.
Keywords: methylation; number alterations; somatic copy; dna methylation ... See more keywords
Low-frequency somatic copy number alterations in normal human lymphocytes revealed by large-scale single-cell whole-genome profiling.
Sign Up to like & getrecommendations! Published in 2021 at "Genome research"
DOI: 10.1101/gr.275453.121
Abstract: Genomic-scale somatic copy number alterations in healthy humans are difficult to investigate because of low occurrence rates and the structural variations' stochastic natures. Using a Tn5-transposase-assisted single-cell whole-genome sequencing method, we sequenced over 20,000 single… read more here.
Keywords: somatic copy; copy number; number alterations; single cell ... See more keywords
Comprehensive analysis of intratumoural heterogeneity of somatic copy number alterations in diffuse glioma reveals clonality‐dependent prognostic patterns
Sign Up to like & getrecommendations! Published in 2022 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12831
Abstract: Intratumoural heterogeneity (ITH) has been implicated in tumour growth and progression as well as therapy resistance. However, the extent of ITH of somatic copy number alterations (ITH‐SCNAs) as a result of tumour evolution and its… read more here.
Keywords: intratumoural heterogeneity; number alterations; somatic copy; diffuse glioma ... See more keywords
Somatic Copy-Number Alterations Occur in the Tumor Microenvironment.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2020-159
Abstract: In colorectal cancer, somatic copy-number alterations (SCNA) were common even in nonmalignant cells. read more here.
Keywords: somatic copy; copy number; alterations occur; number alterations ... See more keywords
CLImAT-HET: detecting subclonal copy number alterations and loss of heterozygosity in heterogeneous tumor samples from whole-genome sequencing data
Sign Up to like & getrecommendations! Published in 2017 at "BMC Medical Genomics"
DOI: 10.1186/s12920-017-0255-4
Abstract: BackgroundCopy number alterations (CNA) and loss of heterozygosity (LOH) represent a large proportion of genetic structural variations of cancer genomes. These aberrations are continuously accumulated during the procedure of clonal evolution and patterned by phylogenetic… read more here.
Keywords: climat het; cna loh; number alterations; tumor ... See more keywords
Microarray analysis to identifiy novel copy number alterations in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.11622
Abstract: 11622Background: SNP microarray can detect Copy Number Alterations (CNAs) which could be predictive of response and can help define therapeutic strategies. Our aim is to improve conventional cytogenetic analysis and identify new genetic alterations relevant… read more here.
Keywords: copy number; number alterations; myeloid leukemia; copy ... See more keywords
Haploinsufficiency and mutation are two sides of the cancer coin as cause and therapeutics target
Sign Up to like & getrecommendations! Published in 2017 at "Translational cancer research"
DOI: 10.21037/13485
Abstract: Unprecedented intensity in the investigation of cancer genomes over the past 20 years has firmly established genome instability as a central hallmark of cancer. Publications from international consortia, particularly The Cancer Genome Atlas (TCGA), have… read more here.
Keywords: copy number; number alterations; two sides; cancer ... See more keywords
Coexisting Molecular Alterations Increase the Risk of Malignancy in Thyroid Nodules with Copy Number Alterations
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DOI: 10.3390/cancers14246149
Abstract: Simple Summary Copy number alterations are known to be present in some thyroid tumors; however, their idiosyncratic clinicopathological implications are not yet well elucidated. In this study we reviewed 67 thyroid nodules with positive copy… read more here.
Keywords: thyroid nodules; number alterations; thyroid; molecular alterations ... See more keywords
Copy number alterations and epithelial‑mesenchymal transition genes in diffuse and intestinal gastric cancers in Mexican patients.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular medicine reports"
DOI: 10.3892/mmr.2022.12707
Abstract: Gastric cancer (GC) is a common malignancy with the highest mortality rate among diseases of the digestive system, worldwide. The present study of GC alterations is crucial to the understanding of tumor biology and the… read more here.
Keywords: cancer; mesenchymal transition; number alterations; mexican patients ... See more keywords