Copy number amplification of androgen receptor in cell-free DNA is a potential prognostic factor in patients with CRPC.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.6_suppl.180
Abstract: 180Background: A circulating cell-free DNA (cfDNA) has been suggested as a potential biomarker for castration-resistant prostate cancer (CRPC). However, clinical implication of the parameters in cf... read more here.
Keywords: number amplification; copy number; free dna; cell free ... See more keywords
LINC00467 Is Upregulated by DNA Copy Number Amplification and Hypomethylation and Shows ceRNA Potential in Lung Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2021.802463
Abstract: Lung adenocarcinoma (LUAD) is the most common histological lung cancer, and it is the leading cause of cancer-related deaths worldwide. Long noncoding RNAs (lncRNAs) have been implicated in tumorigenesis. LINC00467 is a novel lncRNA that… read more here.
Keywords: dna copy; luad; linc00467; lung ... See more keywords
Copy number amplification-activated long non-coding RNA LINC00662 epigenetically inhibits BIK by interacting with EZH2 to regulate tumorigenesis in non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cancer"
DOI: 10.7150/jca.69210
Abstract: Recently, studies have shown that lncRNAs play important roles in regulation of cancer cells proliferation, apoptosis and metastasis. Here, through systematic bioinformatics analysis and screening, we identified a long noncoding RNA LINC00662 with high copy… read more here.
Keywords: number amplification; linc00662; cancer; copy number ... See more keywords
Copy Number Amplification of DNA Damage Repair Pathways Potentiates Therapeutic Resistance in Cancer
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DOI: 10.7150/thno.39341
Abstract: Rationale: Loss of DNA damage repair (DDR) in the tumor is an established hallmark of sensitivity to DNA damaging agents such as chemotherapy. However, there has been scant investigation into gain-of-function alterations of DDR genes… read more here.
Keywords: copy number; number amplification; resistance; cancer ... See more keywords