CNRein: an evolution-aware deep reinforcement learning algorithm for single-cell DNA copy number calling
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DOI: 10.1186/s13059-025-03553-2
Abstract: Low-pass single-cell DNA sequencing technologies and algorithmic advancements have enabled haplotype-specific copy number calling on thousands of cells within tumors. However, measurement uncertainty may result in spurious CNAs inconsistent with realistic evolutionary constraints. We introduce… read more here.
Keywords: copy; single cell; cell dna; number calling ... See more keywords