Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental cell"
DOI: 10.1016/j.devcel.2021.07.006
Abstract: Mitotic errors lead to aneuploidy, a condition of karyotype imbalance, frequently found in cancer cells. Alterations in chromosome copy number induce a wide variety of cellular stresses, including genome instability. Here, we show that cancer… read more here.
Keywords: number changes; copy number; gene copy; number ... See more keywords
Analysis of gene copy number changes in head and neck cancer
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Otolaryngology"
DOI: 10.1111/coa.12686
Abstract: Chromosomal alterations and copy number changes are frequent events in tumours, leading to amplification of focal regions containing several oncogenes. Gains and losses of several regions have been reported in head and neck cancer (HNC),… read more here.
Keywords: neck cancer; number changes; copy number; number ... See more keywords