The number needed to treat adjusted for explanatory variables in regression and survival analysis: Theory and application
Sign Up to like & getrecommendations! Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9418
Abstract: The number needed to treat (NNT) is an efficacy index commonly used in randomized clinical trials. The NNT is the average number of treated patients for each undesirable patient outcome, for example, death, prevented by… read more here.
Keywords: explanatory variables; regression; number needed; needed treat ... See more keywords
Appraising esketamine nasal spray for the management of treatment-resistant depression in adults: Number needed to treat, number needed to harm, and likelihood to be helped or harmed.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2020.03.106
Abstract: INTRODUCTION This post hoc study assessed the evidence-base for esketamine nasal spray for management of treatment-resistant depression (TRD) using number needed to treat (NNT), number needed to harm (NNH), and likelihood to be helped or… read more here.
Keywords: nasal spray; esketamine nasal; esketamine; number needed ... See more keywords
The number needed to treat for net effect (NNTnet) as a metric for measuring combined benefits and harms.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of clinical epidemiology"
DOI: 10.1016/j.jclinepi.2020.05.031
Abstract: Calculating the number needed to treat (NNT) has been widely used to help understand treatment effect results of randomized controlled trials (RCTs). Combined benefit-and-harm profiles from RCT results have to be taken into account to… read more here.
Keywords: nntnet; effect; net effect; number needed ... See more keywords
Number needed to treat for direct oral anticoagulants over warfarin in atrial fibrillation.
Sign Up to like & getrecommendations! Published in 2017 at "Medicina clinica"
DOI: 10.1016/j.medcli.2017.03.039
Abstract: RE-LY2 Ensayo clínico 18.113 Dabigatrán 150 mg/12 h vs. warfarina 1,11 vs. 1 HR: 0,66 p < 0,001 Dabigatrán 110 mg/12 h vs. warfarina 1,53 vs. 1 HR: 0,91 p = 0,34 ROCKET-AF3 Ensayo clínico… read more here.
Keywords: dabigatr 150; ensayo nico; warfarina; 150 warfarina ... See more keywords
Lemborexant and Daridorexant for the Treatment of Insomnia: An Indirect Comparison, Using Number Needed to Treat, Number Needed to Harm, and Likelihood to Be Helped or Harmed
Sign Up to like & getrecommendations! Published in 2023 at "CNS Spectrums"
DOI: 10.1017/s1092852923002183
Abstract: Abstract Background To describe lemborexant and daridorexant for insomnia treatment using number needed to treat (NNT), number needed to harm (NNH), and likelihood to be helped or harmed (LHH). Methods Dichotomous outcomes were identified from… read more here.
Keywords: number needed; number; needed harm; using number ... See more keywords
Letter to the editor: consideration on: ‘What is the risk of cardiovascular events in osteoporotic patients treated with romosozumab?’ by Reid I.R
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Drug Safety"
DOI: 10.1080/14740338.2023.2173737
Abstract: We read with great interest the editorial by I.R. Reid published in Expert Opinion on Drug Safety [1]. The Author addressed cardiovascular safety of romosozumab. He thoroughly discussed data from the ARCH trial [2] that… read more here.
Keywords: romosozumab; number needed; alendronate; risk ... See more keywords
0350 Daridorexant in patients with insomnia disorder: number needed to treat, number needed to harm & likelihood to be helped or harmed
Sign Up to like & getrecommendations! Published in 2023 at "SLEEP"
DOI: 10.1093/sleep/zsad077.0350
Abstract: Patients with insomnia disorder have difficulty initiating or maintaining sleep and have impaired daytime functioning. Daridorexant is a dual orexin receptor antagonist approved for the treatment of insomnia. This analysis reports the number needed to… read more here.
Keywords: number needed; number; patients insomnia; insomnia disorder ... See more keywords
Number (of Whom?) Needed to Treat (with What?): Exposures, Population Interventions, and the Number Needed to Treat.
Sign Up to like & getrecommendations! Published in 2019 at "Epidemiology"
DOI: 10.1097/ede.0000000000001061
Abstract: The number needed to treat (NNT) is a widely used measure of the potential impact of a treatment or intervention, but it is often calculated and discussed in ways which oversimplify critical issues. Specifically, the… read more here.
Keywords: number needed; treat exposures; exposures population; needed treat ... See more keywords
Cariprazine for bipolar depression: What is the number needed to treat, number needed to harm and likelihood to be helped or harmed?
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Clinical Practice"
DOI: 10.1111/ijcp.13397
Abstract: Cariprazine is an oral antipsychotic approved in the US for the treatment of schizophrenia, acute bipolar mania, and most recently, bipolar depression. The aim of this systematic review is to describe the efficacy, tolerability and… read more here.
Keywords: depression number; bipolar depression; cariprazine bipolar; number ... See more keywords
Utility of the number needed to treat in paediatric haematological cancer randomised controlled treatment trials: a systematic review
Sign Up to like & getrecommendations! Published in 2019 at "BMJ Open"
DOI: 10.1136/bmjopen-2018-022839
Abstract: Objectives The primary objective was to assess the utility of the number needed to treat (NNT) to inform decision-making in the context of paediatric oncology and to calculate the NNT in all superiority, parallel, paediatric… read more here.
Keywords: utility number; number needed; cancer; needed treat ... See more keywords
Number needed to treat with ursodeoxycholic acid therapy to prevent liver transplantation or death in primary biliary cholangitis
Sign Up to like & getrecommendations! Published in 2019 at "Gut"
DOI: 10.1136/gutjnl-2019-319057
Abstract: Objective The clinical benefit of ursodeoxycholic acid (UDCA) in primary biliary cholangitis (PBC) has never been reported in absolute measures. The aim of this study was to assess the number needed to treat (NNT) with… read more here.
Keywords: primary biliary; death; ursodeoxycholic acid; prevent ... See more keywords