Dose Number as a Tool to Guide Lead Optimization for Orally Bioavailable Compounds in Drug Discovery.
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DOI: 10.1021/acs.jmedchem.1c01687
Abstract: Small molecule developability challenges have been well documented over the last two decades. One of these critical developability parameters is aqueous solubility. In general, more soluble compounds have improved oral absorption. While enabling formulation technologies… read more here.
Keywords: number tool; dose number; tool guide; discovery ... See more keywords