Mechanistic insights and potential therapeutic targets for NUP98-rearranged hematologic malignancies.
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DOI: 10.1182/blood.2020007093
Abstract: Nucleoporin 98 (NUP98) fusion oncoproteins are observed in a spectrum of hematologic malignancies, particularly pediatric leukemias with poor patient outcomes. While wildtype full length NUP98 is a member of the nuclear pore complex, the chromosomal… read more here.
Keywords: insights potential; hematologic malignancies; fusion; nup98 fusion ... See more keywords
The Menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML.
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DOI: 10.1182/blood.2021012806
Abstract: Translocations involving the NUP98 gene produce NUP98-fusion proteins and are associated with a poor prognosis in acute myeloid leukemia (AML). MLL1 is a molecular dependency in NUP98-fusion leukemia, and therefore we investigated the efficacy of… read more here.
Keywords: fusion; nup98 fusion; leukemia; menin mll1 ... See more keywords