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   Articles with "nup98 fusion" as a keyword



Fetal Differentiation Programs Afford a Protective Barrier to NUP98 Fusion-Driven AML That Dissipates Shortly after Birth

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recommendations! Published in 2024 at "Blood"

DOI: 10.1182/blood-2024-194913

Abstract: Mutations that drive pediatric acute myeloid leukemia (AML) are often age-restricted. NUP98 rearrangements (NUP98r) cause high-risk AML primarily in early-to-mid childhood. NUP98r are rare in adult AML. Furthermore, AML almost never occurs before birth, even… read more here.

Keywords: differentiation; juvenile; aml; nha9 expressing ... See more keywords

HoxBlinc LncRNA Reprograms CTCF Independent TADs to Drive Leukemic Transcription and HSC Dysregulation in NUP98 Fusion Transformed Leukemia

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recommendations! Published in 2024 at "Blood"

DOI: 10.1182/blood-2024-199171

Abstract: Nucleoporin 98 (NUP98) fusion oncoproteins are implicated in various types of leukemia, particularly high-risk childhood leukemias. These NUP98 fusion-driven leukemias often exhibit unique aberrant HOX gene signatures that play critical roles in transforming hematopoietic stem… read more here.

Keywords: leukemic transcription; leukemia; hoxblinc; nup98 fusion ... See more keywords

Mechanistic insights and potential therapeutic targets for NUP98-rearranged hematologic malignancies.

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recommendations! Published in 2020 at "Blood"

DOI: 10.1182/blood.2020007093

Abstract: Nucleoporin 98 (NUP98) fusion oncoproteins are observed in a spectrum of hematologic malignancies, particularly pediatric leukemias with poor patient outcomes. While wildtype full length NUP98 is a member of the nuclear pore complex, the chromosomal… read more here.

Keywords: insights potential; hematologic malignancies; fusion; nup98 fusion ... See more keywords
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The Menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML.

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recommendations! Published in 2021 at "Blood"

DOI: 10.1182/blood.2021012806

Abstract: Translocations involving the NUP98 gene produce NUP98-fusion proteins and are associated with a poor prognosis in acute myeloid leukemia (AML). MLL1 is a molecular dependency in NUP98-fusion leukemia, and therefore we investigated the efficacy of… read more here.

Keywords: fusion; nup98 fusion; leukemia; menin mll1 ... See more keywords

Identification of novel NUP98 fusion partners and comutations in acute myeloid leukemia: an adult cohort study

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recommendations! Published in 2024 at "Blood Advances"

DOI: 10.1182/bloodadvances.2023012479

Abstract: Translocations involving the nucleoporin 98 ( NUP98 ) and >30 fusion partner genes are well characterized for their involvement in hematological diseases including myelodysplastic syndromes and acute myeloid leukemia (AML). 1 Fusion partners are categorized… read more here.

Keywords: fusion; fusion partners; acute myeloid; nup98 fusion ... See more keywords