Abstract A19: Human models of multilineage leukemia induced by NUP98-KDM5A chimeric fusion oncogene
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.pedca17-a19
Abstract: Acute megakaryoblastic (CD41+CD61+) leukemia (AMKL) is a subset (10%) of pediatric acute myeloid leukemia (AML) that typically affects young children ( We engineered human models of AMKL through overexpression of NUP98-KDM5A (N5A) in cord blood… read more here.
Keywords: cell; nup98 kdm5a; fusion oncogene; human models ... See more keywords
Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities.
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DOI: 10.1182/bloodadvances.2019030981
Abstract: Acute megakaryoblastic leukemia (AMKL) represents ∼10% of pediatric acute myeloid leukemia cases and typically affects young children ( read more here.
Keywords: models nup98; amkl; nup98 kdm5a; disease ... See more keywords
Comprehensive molecular and clinical characterization of NUP98 fusions in pediatric acute myeloid leukemia.
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DOI: 10.3324/haematol.2022.281653
Abstract: NUP98 fusions c omprise a family o f rare r ecurrent a lterations i n A ML, associated w ith adverse outcomes. To define the underlying biology and clinical implications of this family of fusions,… read more here.
Keywords: nup98 fusions; nup98 nsd1; nup98 kdm5a; nsd1 nup98 ... See more keywords