Successful treatment of acute myeloid leukemia co-expressing NUP98/NSD1 and FLT3/ITD with preemptive donor lymphocyte infusions
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Hematology"
DOI: 10.1007/s12185-019-02665-3
Abstract: Patients with acute myeloid leukemia (AML) co-expressing NUP98/NSD1 and FLT3/ITD have a dismal prognosis despite undergoing hematopoietic stem cell transplantation (HSCT). There are a few studies on successful treatment of relapsed AML co-expressing NUP98/NSD1 and… read more here.
Keywords: flt3 itd; nsd1 flt3; nup98 nsd1; expressing nup98 ... See more keywords
Awakening KDM5B to defeat leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2202245119
Abstract: In PNAS, Ren et al. (1) report histone demethylase KDM5B (also called JARID1B or PLU1) as a suppressor of acute myeloid leukemia (AML). AML is one of the most frequently diagnosed adult cancers and is… read more here.
Keywords: kdm5b; aml; leukemia; aml cells ... See more keywords
Targeted Inhibition of the NUP98-NSD1 Fusion Oncogene in AML
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DOI: 10.1182/blood-2019-123709
Abstract: Background: NUP98-NSD1 positive AML is a poor prognostic subgroup within pediatric and adult AML (Thol et al., 2013). However, targeted therapeutics for these AML patients are not available to date. As a result of the… read more here.
Keywords: nup98 nsd1; treatment; lnp; fusion ... See more keywords
The Molecular Characteristics and Clinical Relevance of NUP98-Other Translocations in Pediatric Acute Myeloid Leukemia
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DOI: 10.1182/blood-2020-137537
Abstract: Background Cytogenetic and molecular aberrations are important prognostic factors in pediatric acute myeloid leukemia (AML). NUP98 translocations with more than 30 different partner genes have been identified in pediatric AML. The 2 most common fusions,… read more here.
Keywords: cohort; reference cohort; nup98 nsd1; nup98 translocations ... See more keywords
Comprehensive molecular and clinical characterization of NUP98 fusions in pediatric acute myeloid leukemia.
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DOI: 10.3324/haematol.2022.281653
Abstract: NUP98 fusions c omprise a family o f rare r ecurrent a lterations i n A ML, associated w ith adverse outcomes. To define the underlying biology and clinical implications of this family of fusions,… read more here.
Keywords: nup98 fusions; nup98 nsd1; nup98 kdm5a; nsd1 nup98 ... See more keywords
Upfront Screening by Quantitative Real-Time PCR Assay Identifies NUP98::NSD1 Fusion Transcript in Indian AML Patients
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DOI: 10.3390/diagnostics12123001
Abstract: NUP98::NSD1 fusion, a cryptic translocation of t(5;11)(q35;p15.5), occurs predominantly in pediatric AML, having a poor prognostic outcome. There are limited studies on the diagnosis of NUP98::NSD1 fusion in a clinical setting, and most of the… read more here.
Keywords: fusion; aml patients; nsd1 fusion; nup98 nsd1 ... See more keywords