Patterns of care and impact of prognostic factors in the outcome of NUT midline carcinoma: a systematic review and individual patient data analysis of 119 cases
Sign Up to like & getrecommendations! Published in 2018 at "European Archives of Oto-Rhino-Laryngology"
DOI: 10.1007/s00405-018-4882-y
Abstract: IntroductionNUT midline carcinoma is a rare tumour occurring in young adults which is frequently misdiagnosed as poorly differentiated squamous cell carcinoma or germ cell tumour. Though considered highly aggressive, there is limited information about the… read more here.
Keywords: midline carcinoma; carcinoma; analysis; nut midline ... See more keywords
NUT midline carcinomas and their differentials by a single molecular profiling method: a new promising diagnostic strategy illustrated by a case report
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DOI: 10.1007/s00428-020-02869-7
Abstract: NUT midline carcinoma is an aggressive neoplasm defined by chromosomal rearrangements of the nuclear protein in testis (NUT) gene ( NUTM1 ). In this article, we present a strategy to detect this rare tumor through… read more here.
Keywords: midline carcinomas; case; nut midline; strategy ... See more keywords
Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma
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DOI: 10.1016/j.celrep.2017.08.082
Abstract: Summary Kinase inhibitors represent the backbone of targeted cancer therapy, yet only a limited number of oncogenic drivers are directly druggable. By interrogating the activity of 1,505 kinase inhibitors, we found that BRD4-NUT-rearranged NUT midline… read more here.
Keywords: nut midline; kinase; midline carcinoma; nmc cells ... See more keywords
Abstract 648: Digital PCR in genetic diagnosis of NUT midline carcinoma
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DOI: 10.1158/1538-7445.am2018-648
Abstract: Background; NUT midline carcinoma (NMC) is a rare, highly aggressive tumor with t(15;19) translocation involving NUT midline carcinoma family member 1 (NUTM1) gene. NMC is genetically defined and diagnosed by RNA sequencing or by immunohistochemistry… read more here.
Keywords: midline carcinoma; pcr; nut midline; digital pcr ... See more keywords
Clinical features, treatment, and survival outcome of primary pulmonary NUT midline carcinoma
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DOI: 10.1186/s13023-020-01449-x
Abstract: Objective NUT midline carcinoma (NMC), a rare type of squamous cell carcinoma, is genetically characterised by NUT midline carcinoma family member 1 (NUTM1) gene rearrangement. NMC can arise from the lungs; however, there is no… read more here.
Keywords: pulmonary nmc; midline carcinoma; carcinoma; primary pulmonary ... See more keywords
Sinonasal NUT midline carcinoma: A new histological entity
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DOI: 10.4103/ijpm.ijpm_373_19
Abstract: Nuclear protein in testis (NUT) midline carcinoma is poorly differentiated carcinoma defined by rearrangement of NUT gene on 15 to other genes, usually BRD4 on 19. It is first described in 1991. These tumors are… read more here.
Keywords: entity; nut midline; carcinoma; sinonasal nut ... See more keywords