Nutrient Deprivation Elicits a Transcriptional and Translational Inflammatory Response Coupled to Decreased Protein Synthesis
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.07.021
Abstract: SUMMARY Nutrient deprivation inhibits mRNA translation through mTOR and eIF2α signaling, but it is unclear how the translational program is controlled to reflect the degree of a metabolic stress. In a model of breast cellular… read more here.
Keywords: protein; deprivation; inflammatory; protein synthesis ... See more keywords
MYCN amplified neuroblastoma requires the mRNA translation regulator eEF2 kinase to adapt to nutrient deprivation
Sign Up to like & getrecommendations! Published in 2017 at "Cell Death and Differentiation"
DOI: 10.1038/cdd.2017.79
Abstract: MYC family proteins are implicated in many human cancers, but their therapeutic targeting has proven challenging. MYCN amplification in childhood neuroblastoma (NB) is associated with aggressive disease and high mortality. Novel and effective therapeutic strategies… read more here.
Keywords: kinase; mycn; mycn amplified; nutrient deprivation ... See more keywords
Listeria monocytogenes cells under nutrient deprivation showed reduced ability to infect the human intestinal cell line HT‐29
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medical Microbiology"
DOI: 10.1099/jmm.0.000648
Abstract: Purpose. This study aimed to evaluate the effect of two types of stress, cold and nutritional, on the viability and the in vitro virulence of the foodborne pathogenic bacteria Listeria monocytogenes. Methodology. Ten diverse isolates… read more here.
Keywords: vitro virulence; cell line; virulence; human intestinal ... See more keywords
Nutrient Deprivation Promotes MCL-1 Degradation in an Autophagy-Independent Manner
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry (Moscow)"
DOI: 10.1134/s0006297920100119
Abstract: Abstract The antiapoptotic protein Mcl-1, which is an attractive target for cancer treatment, is degraded under nutrient deprivation conditions in different types of cancer. This process sensitizes cancer cells to chemotherapy. It has been found… read more here.
Keywords: independent manner; deprivation; mcl degradation; cancer ... See more keywords
PARP1 and Poly(ADP-ribosyl)ation Signaling during Autophagy in Response to Nutrient Deprivation
Sign Up to like & getrecommendations! Published in 2019 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2019/2641712
Abstract: Autophagy is considered to be the primary degradative pathway that takes place in all eukaryotic cells. Morphologically, the autophagy pathway refers to a process by which cytoplasmic portions are delivered to double-membrane organelles, called autophagosomes,… read more here.
Keywords: adp ribosyl; poly adp; ribosyl ation; adp ... See more keywords
Ubl4A is critical for mitochondrial fusion process under nutrient deprivation stress
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0242700
Abstract: Mitochondrial fusion and fission are dynamic processes regulated by the cellular microenvironment. Under nutrient starvation conditions, mitochondrial fusion is strengthened for energy conservation. We have previously shown that newborns of Ubl4A-deficient mice were more sensitive… read more here.
Keywords: fusion process; mitochondrial fusion; stress; fusion ... See more keywords
Tissue Cytokine IL-33 Modulates the Cytotoxic CD8 T Lymphocyte Activity During Nutrient Deprivation by Regulation of Lineage-Specific Differentiation Programs
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01698
Abstract: IL-1 family member IL-33 exerts a variety of immune activating and regulating properties and has recently been proposed as a prognostic biomarker for cancer diseases, although its precise role in tumor immunity is unclear. Here… read more here.
Keywords: cd8 cells; cytotoxic cd8; expression; nutrient deprivation ... See more keywords
Nutrient deprivation induces apoptosis of nucleus pulposus cells via activation of the BNIP3/AIF signalling pathway
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2017.7550
Abstract: Nutrient deprivation (ND)-induced nucleus pulposus (NP) cell death serves an important role in intervertebral disc degeneration disease. However, the underlying mechanisms have yet to be thoroughly elucidated. The present study created a cell culture model… read more here.
Keywords: death; cell; cell death; nucleus pulposus ... See more keywords
Extracellular ATP is increased by release of ATP-loaded microparticles triggered by nutrient deprivation
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.66274
Abstract: Rationale: Caloric restriction improves the efficacy of anti-cancer therapy. This effect is largely dependent on the increase of the extracellular ATP concentration in the tumor microenvironment (TME). Pathways for ATP release triggered by nutrient deprivation… read more here.
Keywords: release; extracellular atp; nutrient deprivation; release atp ... See more keywords