In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2021.02.021
Abstract: How early events in effector T cell (TEFF) subsets tune memory T cell (TMEM) responses remains incompletely understood. Here, we systematically investigated metabolic factors in fate determination of TEFF and TMEM cells using in vivo pooled CRISPR screening,… read more here.
Keywords: tmem; crispr screening; cell fate; nutrient signaling ... See more keywords
Defects of Nutrient Signaling and Autophagy in Neurodegeneration
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.836196
Abstract: Neurons are post-mitotic cells that allocate huge amounts of energy to the synthesis of new organelles and molecules, neurotransmission and to the maintenance of redox homeostasis. In neurons, autophagy is not only crucial to ensure… read more here.
Keywords: defects nutrient; nutrient signaling; energy; signaling autophagy ... See more keywords
The Effects of Nutrient Signaling Regulators in Combination with Phytocannabinoids on the Senescence-Associated Phenotype in Human Dermal Fibroblasts
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158804
Abstract: Identifying effective anti-aging compounds is a cornerstone of modern longevity, aging, and skin-health research. There is considerable evidence of the effectiveness of nutrient signaling regulators such as metformin, resveratrol, and rapamycin in longevity and anti-aging… read more here.
Keywords: nutrient signaling; signaling regulators; functional activity; effects nutrient ... See more keywords