NVP-AUY922, a novel HSP90 inhibitor, inhibits the progression of malignant pheochromocytoma in vitro and in vivo
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DOI: 10.2147/ott.s130236
Abstract: Purpose Malignant pheochromocytoma (PCC) is a rare tumor with a very poor prognosis and no effective treatments. The aim of this study was to assess the efficacy of a novel second-generation synthetic heat-shock protein 90… read more here.
Keywords: malignant pheochromocytoma; vitro vivo; vivo; hsp90 inhibitor ... See more keywords
Complex Crystal Structure Determination of Hsp90N-NVP-AUY922 and In Vitro Anti-NSCLC Activity of NVP-AUY922
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DOI: 10.3389/fonc.2022.847556
Abstract: New targeted chemotherapy agents greatly improved five-year survival in NSCLC patients, but which were susceptible to drug resistance. NVP-AUY922, terminated in phase II clinical trials, exhibited promising anti-NSCLC (non-small-cell lung cancer) activity targeting to Hsp90N… read more here.
Keywords: hsp90n; nvp auy922; complex crystal; auy922 ... See more keywords
A Low Membrane Hsp70 Expression in Tumor Cells With Impaired Lactate Metabolism Mediates Radiosensitization by NVP-AUY922
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DOI: 10.3389/fonc.2022.861266
Abstract: As overexpression and membrane localization of stress proteins together with high lactate levels promote radioresistance in tumor cells, we studied the effect of the Hsp90 inhibitor NVP-AUY922 on the cytosolic and membrane expression of heat… read more here.
Keywords: tumor cells; membrane hsp70; membrane; nvp auy922 ... See more keywords
Preferential radiosensitization to glioblastoma cancer stem cell-like cells by a Hsp90 inhibitor, N-vinylpyrrolidone-AUY922
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DOI: 10.3892/ol.2022.13222
Abstract: The present study examined the radiosensitization induced by a heat shock protein 90 inhibitor, N-vinylpyrrolidone (NVP)-AUY922, in CD133-positive cells in a hypoxic area of T98G spheroids. CD133-positive cells that are induced in the hypoxic microenvironment… read more here.
Keywords: radiosensitization; nvp auy922; cancer stem; cd133 positive ... See more keywords