NYX-2925 induces metabotropic NMDAR signaling that enhances synaptic NMDAR and AMPAR.
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DOI: 10.1111/jnc.14845
Abstract: N-Methyl-D-Aspartate receptors (NMDARs) mediate both physiological and pathophysiological processes, though selective ligands lack broad clinical utility. NMDARs are composed of multiple subunits, but GluN2 is predominately responsible for functional heterogeneity. Specifically, the GluN2A- and GluN2B-containing… read more here.
Keywords: nmdar signaling; glun2b; synaptic glun2b; nyx 2925 ... See more keywords