A hydrogel matrix prolongs persistence and promotes specific localization of an oncolytic adenovirus in a tumor by restricting nonspecific shedding and an antiviral immune response.
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DOI: 10.1016/j.biomaterials.2017.09.009
Abstract: Currently, intratumoral injection of an oncolytic adenovirus (Ad) is the conventional administration route in clinical trials. Nonetheless, the locally administered Ad disseminates to the surrounding nontarget tissues and has short biological activity due to immunogenicity… read more here.
Keywords: oad trail; trail; immune response; oncolytic adenovirus ... See more keywords