A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity.
Sign Up to like & getrecommendations! Published in 2021 at "Nature medicine"
DOI: 10.1038/s41591-021-01281-1
Abstract: To identify circulating proteins influencing Coronavirus Disease 2019 (COVID-19) susceptibility and severity, we undertook a two-sample Mendelian randomization (MR) study, rapidly scanning hundreds of circulating proteins while reducing bias due to reverse causation and confounding.… read more here.
Keywords: susceptibility; covid susceptibility; oas1; susceptibility severity ... See more keywords
Role of helical structure and dynamics in oligoadenylate synthetase 1 (OAS1) mismatch tolerance and activation by short dsRNAs
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2107111119
Abstract: Significance The innate immune system is a collection of essential frontline defenses against infectious pathogens such as viruses. Currently, however, we do not fully understand how one innate immune sensor of double-stranded RNA (dsRNA), oligoadenylate… read more here.
Keywords: short dsrnas; activate oas1; innate immune; oas1 ... See more keywords