Effect of Chronic Kidney Disease on the Renal Secretion via Organic Anion Transporters 1/3: Implications for Physiologically‐Based Pharmacokinetic Modeling and Dose Adjustment
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DOI: 10.1002/cpt.2642
Abstract: There is growing evidence that active tubular secretory clearance (CLs) may not decline proportionally with the glomerular filtration rate (GFR) in chronic kidney disease (CKD), leading to the overestimation of renal clearance (CLr) when using… read more here.
Keywords: disease; chronic kidney; ckd; oat1 ... See more keywords
The kidney drug transporter OAT1 regulates gut microbiome–dependent host metabolism
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DOI: 10.1172/jci.insight.160437
Abstract: Organic anion transporter 1 (OAT1/SLC22A6, NKT) is a multispecific drug transporter in the kidney with numerous substrates, including pharmaceuticals, endogenous metabolites, natural products, and uremic toxins. Here, we show that OAT1 regulates levels of gut… read more here.
Keywords: transporter; oat1; gut microbiome; host ... See more keywords