(−)-Epigallocatechin-3-gallate Inhibits Human and Rat Renal Organic Anion Transporters
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DOI: 10.1021/acsomega.0c05586
Abstract: Organic anion transporter 1 (OAT1, SLC22A6) and 3 (OAT3, SLC22A8) are multispecific drug transporters highly expressed on the basolateral membranes of the renal proximal tubules. OAT1 and OAT3 mediate the tubular secretion of clinically significant… read more here.
Keywords: oat1 oat3; epigallocatechin gallate; organic anion; inhibits human ... See more keywords
Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes
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DOI: 10.1038/s41598-017-04949-2
Abstract: In vitro data indicates that the kidney proximal tubule (PT) transporters of uremic toxins and solutes (e.g., indoxyl sulfate, p-cresol sulfate, kynurenine, creatinine, urate) include two “drug” transporters of the organic anion transporter (OAT) family:… read more here.
Keywords: uremic toxins; oat1 oat3; handling uremic; toxins solutes ... See more keywords
Mirogabalin, a novel α2δ ligand, is not a substrate of LAT1, but of PEPT1, PEPT2, OAT1, OAT3, OCT2, MATE1 and MATE2-K
Sign Up to like & getrecommendations! Published in 2022 at "Xenobiotica"
DOI: 10.1080/00498254.2022.2129517
Abstract: Abstract Mirogabalin is a α2δ ligand as well as pregabalin. The aim of this study was to clarify whether mirogabalin is a substrate of human LAT1, which involved in absorption and disposition of pregabalin, and… read more here.
Keywords: oat3 oct2; oct2; mirogabalin; pept1 pept2 ... See more keywords
Nano Ellagic Acid Counteracts Cisplatin-Induced Upregulation in OAT1 and OAT3: A Possible Nephroprotection Mechanism
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DOI: 10.3390/molecules25133031
Abstract: Cisplatin is an anticancer drug commonly used for solid tumors. However, it causes nephrotoxicity. OAT1 and OAT3 are organic anion transporters known to contribute to the uptake of cisplatin into renal tubular cells. The present… read more here.
Keywords: oat1 oat3; acid nano; cisplatin; cisplatin induced ... See more keywords