Recovery of OATP1B Activity after Living Kidney Transplantation in Patients with End-Stage Renal Disease
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DOI: 10.1007/s11095-019-2593-8
Abstract: PurposeRecently, several studies have shown that renal failure decreases the metabolic clearance of drugs and the transportation capability of some drug transporters. However, whether organic anion transporting polypeptide (OATP)1B activities decrease in renal failure remains… read more here.
Keywords: oatp1b; activity; kidney transplantation; living kidney ... See more keywords
Physiologically‐based pharmacokinetic model‐based translation of OATP1B‐mediated drug–drug interactions from coproporphyrin I to probe drugs
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DOI: 10.1111/cts.13272
Abstract: The accurate prediction of OATP1B‐mediated drug–drug interactions (DDIs) is challenging for drug development. Here, we report a physiologically‐based pharmacokinetic (PBPK) model analysis for clinical DDI data generated in heathy subjects who received oral doses of… read more here.
Keywords: mediated drug; oatp1b; oatp1b mediated; model ... See more keywords
Utility of Chimeric Mice with Humanized Livers for Predicting Hepatic Organic Anion-Transporting Polypeptide 1B–Mediated Clinical Drug-Drug Interactions
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DOI: 10.1124/dmd.124.001792
Abstract: The influence of transporters on the pharmacokinetics of drugs is being increasingly recognized, and drug-drug interactions (DDIs) via modulation of transporters could lead to clinical adverse events. Organic anion-transporting polypeptide 1B (OATP1B) is a liver-specific… read more here.
Keywords: drug interactions; drug drug; drug; oatp1b ... See more keywords