Dissecting the Contribution of OATP1B1 to Hepatic Uptake of Statins Using the OATP1B1 Selective Inhibitor Estropipate.
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DOI: 10.1021/acs.molpharmaceut.8b01226
Abstract: Identification of a selective inhibitor of organic anion transporting polypeptide (OATP) 1B1 is critical in order to determine the contribution of OATP1B1-mediated uptake of investigational drugs into human hepatocytes for successful in vitro-to-in vivo extrapolation… read more here.
Keywords: hepatic uptake; selective inhibitor; contribution oatp1b1; oatp1b1 hepatic ... See more keywords