Proposal of a Parameter for OATP1B1 Inhibition Screening at the early Drug Discovery Stage.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2019.08.012
Abstract: It is known that potent inhibition of organic anion transporting polypeptide (OATP)1B1 increases exposure to statins, leading to severe adverse effects. The aim of this study is to propose a parameter and its criteria in… read more here.
Keywords: drug; oatp1b1 inhibition; early drug; stage ... See more keywords
In Silico and in Vitro Assessment of OATP1B1 Inhibition in Drug Discovery.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b00168
Abstract: The organic anion-transporting polypeptide 1B1 transporter belongs to the solute carrier superfamily and is highly expressed at the basolateral membrane of hepatocytes. Several clinical studies show drug-drug interactions involving OATP1B1, thereby prompting the International Transporter… read more here.
Keywords: drug; oatp1b1 inhibition; structure activity; drug discovery ... See more keywords