Cooperative inhibitory effects of uremic toxins and other serum components on OATP1B1-mediated transport of SN-38
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DOI: 10.1007/s00280-017-3276-y
Abstract: PurposeHalf-life of SN-38, an active metabolite of irinotecan, remarkably increases in patients with end-stage kidney disease (ESKD), even though SN-38 is excreted in bile. Uremic toxins (UTs), which accumulate in the serum of ESKD patients,… read more here.
Keywords: serum residue; mediated transport; serum; serum components ... See more keywords