Linking organic anion transporting polypeptide 1B1 and 1B3 (OATP1B1 and OATP1B3) interaction profiles to hepatotoxicity ‐ The hyperbilirubinemia use case
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.01.002
Abstract: &NA; Hyperbilirubinemia is a pathological condition of excessive accumulation of conjugated or unconjugated bilirubin in blood. It has been associated with neurotoxicity and non‐neural organ dysfunctions, while it can also be a warning of liver… read more here.
Keywords: anion transporting; 1b1 1b3; hyperbilirubinemia; oatp1b1 oatp1b3 ... See more keywords
Impact of curcumin on the pharmacokinetics of rosuvastatin in rats and dogs based on the conjugated metabolites
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DOI: 10.1080/00498254.2016.1183060
Abstract: Abstract 1. Plasma concentrations of curcumin-O-glucuronide (COG) and curcumin-O-sulfate (COS) significantly increased after Sprague-Dawley rats dealt with the Oatp inhibitor rifampicin, with the Cmax ascending 2.9 and 6.7 times, and the AUC0–∞ ascending 4.4 and… read more here.
Keywords: cog; inhibitor; substrate oatp1b1; significantly increased ... See more keywords
Preference of Conjugated Bile Acids over Unconjugated Bile Acids as Substrates for OATP1B1 and OATP1B3
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DOI: 10.1371/journal.pone.0169719
Abstract: Bile acids, the metabolites of cholesterol, are signaling molecules that play critical role in many physiological functions. They undergo enterohepatic circulation through various transporters expressed in intestine and liver. Human organic anion-transporting polypeptides (OATP) 1B1… read more here.
Keywords: acids substrates; bile acids; unconjugated bile; conjugated bile ... See more keywords
Influence of the OATP Polymorphism on the Population Pharmacokinetics of Methotrexate in Chinese Patients
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DOI: 10.2174/1389200220666190701094756
Abstract: Background: The Pharmacokinetics of Methotrexate (MTX) has been reported to show significant inter-subject variability. MTX is metabolized by SHMT1 and transported by OATP1B1 and OATP1B3 both of which show genetic polymorphisms. The non-genetic and genetic… read more here.
Keywords: genetic factors; pharmacokinetics methotrexate; chinese patients; mtx ... See more keywords
Differential Preincubation Effects of Nicardipine on OATP1B1- and OATP1B3-Mediated Transport in the Presence and Absence of Protein: Implications in Assessing OATP1B1- and OATP1B3-Mediated Drug–Drug Interactions
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15031020
Abstract: Impaired transport activity of hepatic OATP1B1 and OATP1B3 due to drug–drug interactions (DDIs) often leads to increased systemic exposure to substrate drugs (e.g., lipid-lowering statins). Since dyslipidemia and hypertension frequently coexist, statins are often concurrently… read more here.
Keywords: oatp1b1 oatp1b3; drug drug; oatp1b3 mediated; preincubation ... See more keywords