Zebrafish (Danio rerio) Oatp2b1 as a functional ortholog of the human OATP2B1 transporter.
Sign Up to like & getrecommendations! Published in 2021 at "Fish physiology and biochemistry"
DOI: 10.1007/s10695-021-01015-7
Abstract: OATP2B1 belongs to a highly conserved organic anion transporting polypeptide (OATP) family of transporters, involved in the cellular uptake of both endogenous and exogenous compounds. The reported substrates of human OATP2B1 include steroid conjugates, bile… read more here.
Keywords: functional ortholog; zebrafish oatp2b1; oatp2b1; zebrafish danio ... See more keywords
Clinically-relevant OATP2B1 inhibitors in marketed drug space.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b00897
Abstract: OATP2B1 is an intestinal and hepatic drug uptake transporter. Intestinal OATP2B1 has been elucidated as the mechanism of unexpected clinical drug-drug interactions (DDIs), where drug exposure was unexpectedly decreased with unchanged half-life. Hepatic OATP2B1 may… read more here.
Keywords: oatp2b1 inhibitors; inhibition; oatp2b1; drug ... See more keywords
Organic anion transporting polypeptide 2B1 (OATP2B1), an expanded substrate profile, does it align with OATP2B1’s hypothesized function?
Sign Up to like & getrecommendations! Published in 2020 at "Xenobiotica"
DOI: 10.1080/00498254.2020.1745318
Abstract: Abstract An expanded view of the substrate landscape of organic anion transporting polypeptide (OATP) 2B1 was pursued with the goal of understanding if the identification of novel in vitro substrates could shed additional light on… read more here.
Keywords: anion transporting; transporting polypeptide; oatp2b1; oatp2b1 substrates ... See more keywords