Clinically-relevant OATP2B1 inhibitors in marketed drug space.
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DOI: 10.1021/acs.molpharmaceut.9b00897
Abstract: OATP2B1 is an intestinal and hepatic drug uptake transporter. Intestinal OATP2B1 has been elucidated as the mechanism of unexpected clinical drug-drug interactions (DDIs), where drug exposure was unexpectedly decreased with unchanged half-life. Hepatic OATP2B1 may… read more here.
Keywords: oatp2b1 inhibitors; inhibition; oatp2b1; drug ... See more keywords