PCSK9 inhibitor effectively attenuates cardiometabolic impairment in obese-insulin resistant rats.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173347
Abstract: Long-term high-fat diet consumption causes obese-insulin resistance and cardiac mitochondrial dysfunction, leading to impaired left ventricular (LV) function. Atorvastatin effectively improved lipid profiles in obese patients. However, inadequate reduction in low density lipoprotein cholesterol (LDL-C)… read more here.
Keywords: fat diet; insulin; pcsk9 inhibitor; obese insulin ... See more keywords
Dipeptidyl Peptidase-4 Inhibitor, Vildagliptin, Improves Trabecular Bone Mineral Density and Microstructure in Obese, Insulin-Resistant, Pre-diabetic Rats.
Sign Up to like & getrecommendations! Published in 2018 at "Canadian journal of diabetes"
DOI: 10.1016/j.jcjd.2018.01.006
Abstract: OBJECTIVE Obese insulin resistance and type 2 diabetes mellitus profoundly impair bone mechanical properties and bone quality. However, because several antidiabetes drugs, especially thiazolidinediones, further aggravate bone loss in individuals with diabetes, diabetic osteopathy should… read more here.
Keywords: insulin; bone mineral; obese insulin; bone ... See more keywords
Combination of exercise and calorie restriction exerts greater efficacy on cardioprotection than monotherapy in obese-insulin resistant rats through the improvement of cardiac calcium regulation.
Sign Up to like & getrecommendations! Published in 2019 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2019.02.003
Abstract: BACKGROUND Long-term high-fat diet (HFD) consumption causes obese-insulin resistance which is known to be a major risk factor for cardiovascular diseases due to its impact on the impairment of left ventricular (LV) contractile function and… read more here.
Keywords: hfd; calorie restriction; obese insulin; function ... See more keywords
Lactobacillus paracasei HII01, xylooligosaccharides, and synbiotics reduce gut disturbance in obese rats.
Sign Up to like & getrecommendations! Published in 2018 at "Nutrition"
DOI: 10.1016/j.nut.2018.03.005
Abstract: OBJECTIVES The beneficial effects of pro-, pre-, and synbiotics on obesity with insulin resistance have been reported previously. However, the strain-specific effect of probiotics and the combination with various types of prebiotic fiber yield controversial… read more here.
Keywords: hii01; insulin; gut; obese insulin ... See more keywords
Thromboelastography in obese horses with insulin dysregulation compared to healthy controls.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of veterinary internal medicine"
DOI: 10.1111/jvim.16421
Abstract: BACKGROUND Both obesity and metabolic syndrome are associated with hypercoagulability in people, increasing the risk of cardiovascular disease and thromboembolic events. Whether hypercoagulability exists in obese, insulin-dysregulated horses is unknown. HYPOTHESIS/OBJECTIVES To determine if coagulation… read more here.
Keywords: healthy controls; insulin; insulin dysregulation; compared healthy ... See more keywords
Transcriptomic effects of metformin in skeletal muscle arteries of obese insulin-resistant rats
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Biology and Medicine"
DOI: 10.1177/1535370216689825
Abstract: We examined the effects of metformin, a commonly used antidiabetic drug, on gene expression in multiple arteries. Specifically, transcriptional profiles of feed arteries and second branch order arterioles in the soleus, gastrocnemius, and diaphragm muscles… read more here.
Keywords: obese insulin; expression; insulin resistant; gene ... See more keywords