Semaglutide (GLP‐1 receptor agonist) stimulates browning on subcutaneous fat adipocytes and mitigates inflammation and endoplasmic reticulum stress in visceral fat adipocytes of obese mice
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3751
Abstract: Semaglutide (GLP‐1 agonist) was approved for treating obesity. Although the effects on weight loss and metabolism are known, the responses of adipocytes to semaglutide are yet limited. C57BL/6 male mice (n = 20/group) were fed a control… read more here.
Keywords: stress; fat adipocytes; obese mice; semaglutide ... See more keywords
Response to: Obesity and Vitamin D Metabolism Modifications
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3743
Abstract: We thank Landrier and colleagues for their thoughtful comments regarding our recent publication regarding the role of decreased expression of CYP2R1 as a basis for reduced circulating levels of 25(OH)D in obese mice. First, Landrier… read more here.
Keywords: fat diet; obese mice; obesity; mice ... See more keywords
AdipoRon enhances healthspan in middle‐aged obese mice: striking alleviation of myosteatosis and muscle degenerative markers
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13148
Abstract: Obesity among older adults has increased tremendously. Obesity accelerates ageing and predisposes to age‐related conditions and diseases, such as loss of endurance capacity, insulin resistance and features of the metabolic syndrome. Namely, ectopic lipids play… read more here.
Keywords: myosteatosis; obese mice; muscle; adiporon enhances ... See more keywords
Dietary apple polyphenols promote fat browning in high-fat diet-induced obese mice through activation of AMP-activated protein kinase (AMPK) α.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.10248
Abstract: BACKGROUND Promoting brown and beige adipogenesis contributes to adaptive thermogenesis, which provides a defense against obesity and related disorders. Apple polyphenols (APs) play a significant role in treating variety of metabolic diseases. The present study… read more here.
Keywords: obese mice; apple polyphenols; activated protein; protein kinase ... See more keywords
Lactobacillus plantarum HF02 alleviates lipid accumulation and intestinal microbiota dysbiosis in high-fat diet-induced obese mice.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12538
Abstract: BACKGROUND Obesity is closely associated with lipid accumulation and intestinal microbiota dysbiosis. It has been proved that probiotics supplement contributes to alleviate obesity. The objective of this study was to investigate the mechanism by which… read more here.
Keywords: hf02; intestinal microbiota; obese mice; accumulation ... See more keywords
Differences in macrophage polarization in the adipose tissue of obese mice under various levels of exercise intensity
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Physiology and Biochemistry"
DOI: 10.1007/s13105-020-00731-7
Abstract: Animal studies have demonstrated that the ratio of M1 (M1Φ) to M2 (M2Φ) macrophage-specific gene expression in adipose tissue (AT) may be altered by chronic exercise; however, whether macrophage polarization is induced under these conditions… read more here.
Keywords: hfd; exercise intensity; obese mice; group ... See more keywords
Patchouli alcohol protects against ischemia/reperfusion-induced brain injury via inhibiting neuroinflammation in normal and obese mice
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2017.12.039
Abstract: Almost all of the candidate drugs for ischemic stroke failed to be translated from bench to beside. One important reason is that animals used in experimental studies cannot mimic ischemic patients due to lack of… read more here.
Keywords: obese mice; inflammation; cerebral injury; brain ... See more keywords
Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2018.12.061
Abstract: Insulin action in the hypothalamus results in the suppression of hepatic glucose production (HGP). Obesity is often associated with a diminished response to insulin, leading to impaired suppression of HGP in obese mice. Here, we… read more here.
Keywords: insulin; obese mice; glucose production; mice ... See more keywords
The mTORC1/AMPK pathway plays a role in the beneficial effects of semaglutide (GLP-1 receptor agonist) on the liver of obese mice.
Sign Up to like & getrecommendations! Published in 2022 at "Clinics and research in hepatology and gastroenterology"
DOI: 10.1016/j.clinre.2022.101922
Abstract: PURPOSE - The liver regulates lipid metabolism. Decreasing mTOR (mechanistic target of rapamycin complex 1) and enhancing AMPK (AMP-activated protein kinase) help degrade hepatic diet-induced accumulated lipids. Therefore, the glucagon-like peptide type 1 receptor agonist… read more here.
Keywords: effects semaglutide; obese mice; mtorc1 ampk; receptor agonist ... See more keywords
Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity.
Sign Up to like & getrecommendations! Published in 2017 at "Cell metabolism"
DOI: 10.1016/j.cmet.2016.12.001
Abstract: Obesity is associated with physical inactivity, which exacerbates the health consequences of weight gain. However, the mechanisms that mediate this association are unknown. We hypothesized that deficits in dopamine signaling contribute to physical inactivity in… read more here.
Keywords: inactivity obesity; obese mice; physical inactivity; obesity ... See more keywords
Mitochondrial mRNA translation initiation contributes to oxidative metabolism in the myocardia of aged, obese mice
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2019.03.009
Abstract: Abstract Being both advanced in age and obese each contribute to cardiac hypertrophy in a unique manner. Electron transport complexes I and IV are implicated in deficient electron transport during cardiomyopathies and contain the majority… read more here.
Keywords: obese mice; translation initiation; mrna translation; aged obese ... See more keywords