Distinct Roles of DRP1 in Conventional and Alternative Mitophagy in Obesity Cardiomyopathy.
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DOI: 10.1161/circresaha.123.322512
Abstract: RATIONALE Obesity induces cardiomyopathy characterized by hypertrophy and diastolic dysfunction. Whereas mitophagy mediated through an Atg7-dependent mechanism serves as an essential mechanism to maintain mitochondrial quality during the initial development of obesity cardiomyopathy, Rab9-dependent alternative… read more here.
Keywords: hfd consumption; alternative mitophagy; obesity cardiomyopathy; mitophagy ... See more keywords