Blackcurrant (Ribes nigrum) Prevents Obesity‐Induced Nonalcoholic Steatohepatitis in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Obesity"
DOI: 10.1002/oby.22353
Abstract: With increasing prevalence of nonalcoholic steatohepatitis (NASH), effective strategies to prevent NASH are needed. This study investigated whether the consumption of blackcurrant (Ribes nigrum) can prevent the development of obesity‐induced NASH in vivo. read more here.
Keywords: blackcurrant ribes; ribes nigrum; nonalcoholic steatohepatitis; obesity induced ... See more keywords
Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.02.014
Abstract: Exercise promotes adipose remodeling and improves obesity-induced metabolic disorders through mechanisms that remain obscure. Here, we identify the FGF21 signaling in adipose tissues as an obligatory molecular transducer of exercise conferring its metabolic benefits in… read more here.
Keywords: induced metabolic; exercise alleviates; adipose tissues; obesity induced ... See more keywords
Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Cell Metabolism"
DOI: 10.1016/j.cmet.2018.12.008
Abstract: Summary Cellular senescence entails a stable cell-cycle arrest and a pro-inflammatory secretory phenotype, which contributes to aging and age-related diseases. Obesity is associated with increased senescent cell burden and neuropsychiatric disorders, including anxiety and depression.… read more here.
Keywords: neurogenesis; senescent cells; senescence; obesity induced ... See more keywords
Lisofylline mitigates cardiac inflammation in a mouse model of obesity through improving insulin secretion and activating cardiac AMPK signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Cytokine"
DOI: 10.1016/j.cyto.2020.155398
Abstract: Obesity has emerged as a leading cause of death in the last few decades, mainly due to associated cardiovascular diseases. Obesity, inflammation, and insulin resistance are strongly interlinked. Lisofylline (LSF), an anti-inflammatory agent, demonstrated protection… read more here.
Keywords: inflammation; cardiac ampk; obesity induced; cardiac inflammation ... See more keywords
Unraveling the mechanisms of obesity-induced hyperoxaluria.
Sign Up to like & getrecommendations! Published in 2018 at "Kidney international"
DOI: 10.1016/j.kint.2018.01.012
Abstract: Kidney stones is increasingly associated with obesity. With an increasing prevalence of obesity and metabolic syndrome in the past 30 years, urinary oxalate has significantly increased. However, its underlying pathophysiologic mechanisms of hyperoxaluria have not… read more here.
Keywords: induced hyperoxaluria; obesity induced; mechanisms obesity; obesity ... See more keywords
Diet and Obesity-Induced Methylglyoxal Production and Links to Metabolic Disease.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.1c00221
Abstract: The obesity rate in the United States is 42.4% and has become a national epidemic. Obesity is a complex condition that is influenced by socioeconomic status, ethnicity, genetics, age, and diet. Increased consumption of a… read more here.
Keywords: obesity; obesity induced; production; disease ... See more keywords
Docosahexaenoic Acid-Enriched Phosphatidylcholine Exerted Superior Effects to Triglyceride in Ameliorating Obesity-Induced Osteoporosis through Up-Regulating the Wnt/β-Catenin Pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c06081
Abstract: A growing number of studies reported that obesity is one of the major inducements for osteoporosis by promoting excessive adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). Marine-derived DHA-enriched phosphatidylcholine (DHA-PC) exhibited activities to… read more here.
Keywords: obesity induced; enriched phosphatidylcholine; induced osteoporosis; dha ... See more keywords
Development of Novel IP6K Inhibitors for the Treatment of Obesity and Obesity-Induced Metabolic Dysfunctions.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00220
Abstract: Obesity and obesity-induced metabolic dysfunctions are significant risk factors for nonalcoholic fatty liver disease and cardiovascular diseases. Thus, obesity is an economic and social burden in developed countries. Blocking the synthesis of inositol pyrophosphates by… read more here.
Keywords: obesity; obesity induced; obesity obesity; metabolic dysfunctions ... See more keywords
Obesity-induced decreases in muscle performance are not reversed by weight loss
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Obesity"
DOI: 10.1038/ijo.2017.81
Abstract: Background/Objectives:Obesity can affect muscle phenotypes, and may thereby constrain movement and energy expenditure. Weight loss is a common and intuitive intervention for obesity, but it is not known whether the effects of obesity on muscle… read more here.
Keywords: muscle; induced decreases; weight loss; obesity induced ... See more keywords
Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22106-2
Abstract: Increased adiposity confers risk for systemic insulin resistance and type 2 diabetes (T2D), but mechanisms underlying this pathogenic inter-organ crosstalk are incompletely understood. We find PHLPP2 (PH domain and leucine rich repeat protein phosphatase 2),… read more here.
Keywords: phlpp2; adipocyte phlpp2; fatty liver; induced fatty ... See more keywords
Overexpression of G protein-coupled receptor 40 protects obesity-induced cardiomyopathy through the SIRT1/LKB1/AMPK pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Human gene therapy"
DOI: 10.1089/hum.2021.176
Abstract: Obesity has become a serious global public health problem, and cardiomyopathy caused by obesity has been paid more and more attention in recent years. As an important protein involved in glucose and lipid metabolism, G… read more here.
Keywords: obesity induced; ampk pathway; overexpression; gpr40 ... See more keywords