HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling
Sign Up to like & getrecommendations! Published in 2021 at "Diabetologia"
DOI: 10.1007/s00125-021-05470-y
Abstract: Adipocytes are critical cornerstones of energy metabolism. While obesity-induced adipocyte dysfunction is associated with insulin resistance and systemic metabolic disturbances, adipogenesis, the formation of new adipocytes and healthy adipose tissue expansion are associated with metabolic… read more here.
Keywords: obesity linked; transcription factor; hand2; obesity ... See more keywords
Integrated network pharmacology and molecular modeling approach for the discovery of novel potential MAPK3 inhibitors from whole green jackfruit flour targeting obesity-linked diabetes mellitus
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DOI: 10.1371/journal.pone.0280847
Abstract: The current study investigates the effectiveness of phytocompounds from the whole green jackfruit flour methanol extract (JME) against obesity-linked diabetes mellitus using integrated network pharmacology and molecular modeling approach. Through network pharmacology, druglikeness and pharmacokinetics,… read more here.
Keywords: network; pharmacology; diabetes mellitus; obesity linked ... See more keywords
Obesity-Linked PPARγ Ser273 Phosphorylation Promotes Beneficial Effects on the Liver, despite Reduced Insulin Sensitivity in Mice
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DOI: 10.3390/biom13040632
Abstract: Since the removal of thiazolidinediones (TZDs) from the market, researchers have been exploring alternative anti-diabetic drugs that target PPARγ without causing adverse effects while promoting insulin sensitization by blocking serine 273 phosphorylation (Ser273 or S273).… read more here.
Keywords: insulin sensitivity; s273 phosphorylation; obesity linked; phosphorylation ... See more keywords
Functional Characterization of the Obesity-Linked Variant of the β3-Adrenergic Receptor
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DOI: 10.3390/ijms22115721
Abstract: Adrenergic receptor β3 (ADRβ3) is a member of the rhodopsin-like G protein-coupled receptor family. The binding of the ligand to ADRβ3 activates adenylate cyclase and increases cAMP in the cells. ADRβ3 is highly expressed in… read more here.
Keywords: adrenergic receptor; linked variant; obesity linked; adr ... See more keywords