Mitochondrial dysfunction caused by SIRT3 inhibition drives proinflammatory macrophage polarization in obesity
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DOI: 10.1002/oby.23707
Abstract: Metabolic reprogramming is a main feature of proinflammatory macrophage polarization, a process that leads to inflammation in dysfunctional adipose tissue. Therefore, the study aim was to explore whether sirtuin 3 (SIRT3), a mitochondrial deacetylase, participates… read more here.
Keywords: obesity mitochondrial; proinflammatory macrophage; macrophage polarization;