Phase I–II study of OBI-888, a humanized monoclonal IgG1 antibody against the tumor-associated carbohydrate antigen Globo H, in patients with advanced solid tumors
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DOI: 10.1007/s00280-024-04714-z
Abstract: OBI-888 is a humanized, monoclonal IgG1 antibody specific to the tumor-associated carbohydrate antigen Globo H. We conducted a phase I-II study of OBI-888 in patients with advanced cancer. Patients were treated with OBI-888 5, 10,… read more here.
Keywords: 888 humanized; obi 888; humanized monoclonal; tumor associated ... See more keywords
Abstract 4814: Specificity, biodistribution, tumor targeting, and pharmacokinetics of a novel humanized anti-Globo H antibody, OBI-888, for cancer immunotherapy
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DOI: 10.1158/1538-7445.sabcs18-4814
Abstract: Background: OBI-888 is a humanized monoclonal IgG1 antibody that binds to Globo H (GH), a tumor associated carbohydrate antigen. It is developed as a therapy to treat GH positive cancers. In the present study, we… read more here.
Keywords: tumor bearing; obi 888; specificity; biodistribution ... See more keywords