Crosstalk between the IGF1 and CXCL12 Pathways Defines Objective Responses to the Farnesyl Transferase Inhibitor Tipifarnib in AML and PTCL Patients
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DOI: 10.1182/blood-2018-99-116969
Abstract: Background CXCL12 is a chemokine that is essential for the maturation of myeloid and lymphoid cells. Tipifarnib is a potent and selective inhibitor of the enzyme farnesyltransferase (FT). Treatment with this agent may translate to… read more here.
Keywords: igf1 cxcl12; objective responses; igf1; expression ... See more keywords