Engineering of obligate intracellular bacteria: progress, challenges and paradigms
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Microbiology"
DOI: 10.1038/nrmicro.2017.59
Abstract: It is estimated that approximately one billion people are at risk of infection with obligate intracellular bacteria, but little is known about the underlying mechanisms that govern their life cycles. The difficulty in studying Chlamydia… read more here.
Keywords: engineering obligate; intracellular bacteria; progress; spp ... See more keywords
Cell-selective proteomics reveal novel effectors secreted by an obligate intracellular bacterial pathogen
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-50493-9
Abstract: Pathogenic bacteria secrete protein effectors to hijack host machinery and remodel their infectious niche. Rickettsia spp. are obligate intracellular bacteria that can cause life-threatening disease, but their absolute dependence on the host cell has impeded… read more here.
Keywords: cell selective; host; selective proteomics; pathogen ... See more keywords
The life cycle-dependent transcriptional profile of the obligate intracellular amoeba symbiont Amoebophilus asiaticus
Sign Up to like & getrecommendations! Published in 2022 at "FEMS Microbiology Ecology"
DOI: 10.1093/femsec/fiac001
Abstract: Abstract Free-living amoebae often harbor obligate intracellular bacterial symbionts. Amoebophilus (A.) asiaticus is a representative of a lineage of amoeba symbionts in the phylum Bacteroidota. Here, we analyse the transcriptome of A. asiaticus strain 5a2… read more here.
Keywords: cycle; asiaticus; life cycle; amoeba ... See more keywords
A Member of an Ancient Family of Bacterial Amino Acids Transporters Contributes to Chlamydia Nutritional Virulence and Immune Evasion
Sign Up to like & getrecommendations! Published in 2023 at "Infection and Immunity"
DOI: 10.1128/iai.00483-22
Abstract: Many obligate intracellular bacteria, including members of the genus Chlamydia, cannot synthesize a variety of amino acids de novo and acquire these from host cells via largely unknown mechanisms. Previously, we determined that a missense… read more here.
Keywords: ancient family; amino acids; obligate intracellular; transporters contributes ... See more keywords
Identification and Structural Modeling of the RNA Polymerase Omega Subunits in Chlamydiae and Other Obligate Intracellular Bacteria
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DOI: 10.1128/mbio.03499-22
Abstract: Chlamydiae are obligate intracellular bacteria that replicate only inside eukaryotic cells. Previously, it has not been possible to identify a candidate gene encoding the chlamydial RNA polymerase ω subunit, and it has been hypothesized that… read more here.
Keywords: rna polymerase; subunit; chlamydial rna; obligate intracellular ... See more keywords
Microsporidia: Obligate Intracellular Pathogens Within the Fungal Kingdom.
Sign Up to like & getrecommendations! Published in 2017 at "Microbiology spectrum"
DOI: 10.1128/microbiolspec.funk-0018-2016
Abstract: Microsporidia are obligate intracellular pathogens related to Fungi. These organisms have a unique invasion organelle, the polar tube, which upon appropriate environmental stimulation rapidly discharges out of the spore, pierces a host cell's membrane, and… read more here.
Keywords: invasion; obligate intracellular; intracellular pathogens; microsporidia obligate ... See more keywords
Bringing genetics to heretofore intractable obligate intracellular bacterial pathogens: Chlamydia and beyond
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010669
Abstract: As their designation implies, obligate intracellular bacteria are microbes that have developed lifestyles so closely entwined with the cells of the hosts they infect that they can reproduce only within the confines of these cells.… read more here.
Keywords: obligate intracellular; spp; intracellular bacteria; host ... See more keywords
Vaccine development: obligate intracellular bacteria new tools, old pathogens: the current state of vaccines against obligate intracellular bacteria
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2024.1282183
Abstract: Obligate intracellular bacteria have remained those for which effective vaccines are unavailable, mostly because protection does not solely rely on an antibody response. Effective antibody-based vaccines, however, have been developed against extracellular bacteria pathogens or… read more here.
Keywords: intracellular bacteria; vaccine development; vaccines obligate; obligate intracellular ... See more keywords
The MraY Inhibitor Muraymycin D2 and Its Derivatives Induce Enlarged Cells in Obligate Intracellular Chlamydia and Wolbachia and Break the Persistence Phenotype in Chlamydia
Sign Up to like & getrecommendations! Published in 2024 at "Antibiotics"
DOI: 10.3390/antibiotics13050421
Abstract: Chlamydial infections and diseases caused by filarial nematodes are global health concerns. However, treatment presents challenges due to treatment failures potentially caused by persisting Chlamydia and long regimens against filarial infections accompanied by low compliance.… read more here.
Keywords: induce enlarged; chlamydia wolbachia; persistence; obligate intracellular ... See more keywords