Revisiting non‐obstructive azoospermia: Is there a best way to retrieve testicular sperm?
Sign Up to like & getrecommendations! Published in 2025 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12632
Abstract: Microdissection TESE has been considered the “gold standard” for retrieving testicular sperm in cases of non‐obstructive azoospermia (NOA) despite limited scientific support. Here we compare all aspects of microdissection TESE with testis fine needle aspiration… read more here.
Keywords: obstructive azoospermia; non obstructive; revisiting non; testicular sperm ... See more keywords
Genetic insights into non-obstructive azoospermia: Implications for diagnosis and TESE outcomes
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-025-03409-5
Abstract: Non-obstructive azoospermia (NOA) is considered one of the most severe forms of male infertility. Despite the limited range of testicular phenotypes, NOA exhibits considerable genetic heterogeneity. The aim of this study was to uncover the… read more here.
Keywords: obstructive azoospermia; insights non; genetic insights; non obstructive ... See more keywords
Seminal plasma miRNAs in Klinefelter syndrome and in obstructive and non-obstructive azoospermia
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology Reports"
DOI: 10.1007/s11033-020-05552-x
Abstract: MicroRNAs are small, non-coding, single-strand oligonucleotides which regulate gene expression. There is little evidence in the literature about their role in azoospermia and no studies have investigated their presence in the seminal plasma of men… read more here.
Keywords: klinefelter syndrome; non obstructive; azoospermia; seminal plasma ... See more keywords
Successful microdissection testicular sperm extraction for men with non-obstructive azoospermia.
Sign Up to like & getrecommendations! Published in 2018 at "Reproductive biology"
DOI: 10.1016/j.repbio.2018.03.003
Abstract: Non-obstructive azoospermia (NOA) is the most severe form of male infertility, defined by lack of spermatozoa in the ejaculate caused by impaired spermatogenesis. The chance of biological fatherhood of these men has been improved since… read more here.
Keywords: testicular sperm; non obstructive; microdissection testicular; sperm extraction ... See more keywords
Testicular Spermatozoa Are of Better Quality Than Epididymal Spermatozoa in Patients With Obstructive Azoospermia.
Sign Up to like & getrecommendations! Published in 2017 at "Urology"
DOI: 10.1016/j.urology.2016.11.019
Abstract: OBJECTIVE To assess sperm quality as a function of the sampling site (testis or epididymis) in obstructive azoospermia (OA). MATERIALS AND METHODS DNA fragmentation rates in spermatozoa sampled from the testis and epididymis (from patients… read more here.
Keywords: quality; spermatozoa; epididymal spermatozoa; patients obstructive ... See more keywords
Identification of a missense variant in CLDN2 in obstructive azoospermia
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Human Genetics"
DOI: 10.1038/s10038-019-0642-0
Abstract: Obstructive azoospermia (OA), defined as an obstruction in any region of the male genital tract, accounts for 40% of all azoospermia cases. Of all OA cases, ~30% are thought to have a genetic origin, however,… read more here.
Keywords: variant cldn2; obstructive azoospermia; variant; missense variant ... See more keywords
Novel biomarker ZCCHC13 revealed by integrating DNA methylation and mRNA expression data in non-obstructive azoospermia
Sign Up to like & getrecommendations! Published in 2018 at "Cell Death Discovery"
DOI: 10.1038/s41420-018-0033-x
Abstract: The objective of this study was to identify genes regulated by methylation that were involved in spermatogenesis failure in non-obstructive azoospermia (NOA). Testis biopsies of patients with NOA and OA (with normal spermatogenesis) were evaluated… read more here.
Keywords: methylation; non obstructive; expression; obstructive azoospermia ... See more keywords
Stress granule–mediated ZBP1 activation drives necroptotic cell death in non-obstructive azoospermia and testicular aging
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2514837122
Abstract: Significance The causes of male infertility and reproductive aging remain largely elusive. This study identifies a necroptotic pathway, initiated by stress granule formation and mediated by ZBP1 and RIPK3, as a key mechanism driving the… read more here.
Keywords: obstructive azoospermia; stress granule; mediated zbp1; non obstructive ... See more keywords
Genetic variants underlying spermatogenic arrests in men with non-obstructive azoospermia
Sign Up to like & getrecommendations! Published in 2023 at "Cell Cycle"
DOI: 10.1080/15384101.2023.2171544
Abstract: ABSTRACT Spermatogenic arrest is a severe form of non-obstructive azoospermia (NOA), which occurs in 10–15% of infertile men. Interruption in spermatogenic progression at premeiotic, meiotic, or postmeiotic stage can lead to arrest in men with… read more here.
Keywords: non obstructive; genetic variants; obstructive azoospermia; spermatogenic arrests ... See more keywords
Profiling of circulating extracellular vesicle microRNAs reveals diagnostic potential and pathways in non-obstructive and obstructive azoospermia
Sign Up to like & getrecommendations! Published in 2024 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioae130
Abstract: Abstract The accurate diagnosis of non-obstructive azoospermia and obstructive azoospermia is crucial for selecting appropriate clinical treatments. This study aimed to investigate the pivotal role of microRNAs in circulating plasma extracellular vesicles in distinguishing between… read more here.
Keywords: obstructive azoospermia; azoospermia; extracellular vesicle; non obstructive ... See more keywords
P-069 Whole exome sequencing (WES) may explain non-obstructive azoospermia (NOA), solving the etiology and guiding the clinical-andrological management of patients
Sign Up to like & getrecommendations! Published in 2025 at "Human Reproduction"
DOI: 10.1093/humrep/deaf097.378
Abstract: Can WES-based analysis identify genetic causes of NOA and predict sperm recovery rates after testicular sperm extraction (TESE)? Mutational status in candidate genes correlates with sperm retrieval success, supporting the diagnostic and prognostic value of… read more here.
Keywords: azoospermia noa; obstructive azoospermia; whole exome; etiology ... See more keywords