Seminal plasma miRNAs in Klinefelter syndrome and in obstructive and non-obstructive azoospermia
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology Reports"
DOI: 10.1007/s11033-020-05552-x
Abstract: MicroRNAs are small, non-coding, single-strand oligonucleotides which regulate gene expression. There is little evidence in the literature about their role in azoospermia and no studies have investigated their presence in the seminal plasma of men… read more here.
Keywords: klinefelter syndrome; non obstructive; azoospermia; seminal plasma ... See more keywords
Successful microdissection testicular sperm extraction for men with non-obstructive azoospermia.
Sign Up to like & getrecommendations! Published in 2018 at "Reproductive biology"
DOI: 10.1016/j.repbio.2018.03.003
Abstract: Non-obstructive azoospermia (NOA) is the most severe form of male infertility, defined by lack of spermatozoa in the ejaculate caused by impaired spermatogenesis. The chance of biological fatherhood of these men has been improved since… read more here.
Keywords: testicular sperm; non obstructive; microdissection testicular; sperm extraction ... See more keywords
Testicular Spermatozoa Are of Better Quality Than Epididymal Spermatozoa in Patients With Obstructive Azoospermia.
Sign Up to like & getrecommendations! Published in 2017 at "Urology"
DOI: 10.1016/j.urology.2016.11.019
Abstract: OBJECTIVE To assess sperm quality as a function of the sampling site (testis or epididymis) in obstructive azoospermia (OA). MATERIALS AND METHODS DNA fragmentation rates in spermatozoa sampled from the testis and epididymis (from patients… read more here.
Keywords: quality; spermatozoa; epididymal spermatozoa; patients obstructive ... See more keywords
Identification of a missense variant in CLDN2 in obstructive azoospermia
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Human Genetics"
DOI: 10.1038/s10038-019-0642-0
Abstract: Obstructive azoospermia (OA), defined as an obstruction in any region of the male genital tract, accounts for 40% of all azoospermia cases. Of all OA cases, ~30% are thought to have a genetic origin, however,… read more here.
Keywords: variant cldn2; obstructive azoospermia; variant; missense variant ... See more keywords
Novel biomarker ZCCHC13 revealed by integrating DNA methylation and mRNA expression data in non-obstructive azoospermia
Sign Up to like & getrecommendations! Published in 2018 at "Cell Death Discovery"
DOI: 10.1038/s41420-018-0033-x
Abstract: The objective of this study was to identify genes regulated by methylation that were involved in spermatogenesis failure in non-obstructive azoospermia (NOA). Testis biopsies of patients with NOA and OA (with normal spermatogenesis) were evaluated… read more here.
Keywords: methylation; non obstructive; expression; obstructive azoospermia ... See more keywords
Genetic variants underlying spermatogenic arrests in men with non-obstructive azoospermia
Sign Up to like & getrecommendations! Published in 2023 at "Cell Cycle"
DOI: 10.1080/15384101.2023.2171544
Abstract: ABSTRACT Spermatogenic arrest is a severe form of non-obstructive azoospermia (NOA), which occurs in 10–15% of infertile men. Interruption in spermatogenic progression at premeiotic, meiotic, or postmeiotic stage can lead to arrest in men with… read more here.
Keywords: non obstructive; genetic variants; obstructive azoospermia; spermatogenic arrests ... See more keywords
A pathogenic DMC1 frameshift mutation causes non-obstructive azoospermia but not primary ovarian insufficiency in humans.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular human reproduction"
DOI: 10.1093/molehr/gaab058
Abstract: Non-obstructive azoospermia (NOA) and diminished ovarian reserve (DOR) are two disorders that can lead to infertility in male and female. Genetic factors have been identified to contribute to NOA and DOR. However, the same genetic… read more here.
Keywords: dmc1; non obstructive; dor; noa dor ... See more keywords
Bi-allelic variants in SHOC1 cause non-obstructive azoospermia with meiosis arrest in humans and mice.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular human reproduction"
DOI: 10.1093/molehr/gaac015
Abstract: Meiosis is pivotal to gametogenesis and fertility. Meiotic recombination is a mandatory process that ensures faithful chromosome segregation and generates genetic diversity in gametes. Non-obstructive azoospermia (NOA) caused by meiotic arrest is a common cause… read more here.
Keywords: meiosis; non obstructive; allelic variants; shoc1 ... See more keywords
Variation analysis of SOX8 gene in Chinese men with non‐obstructive azoospermia or oligozoospermia
Sign Up to like & getrecommendations! Published in 2020 at "Andrologia"
DOI: 10.1111/and.13531
Abstract: Sox8, encoding a SRY‐related HMG box transcription factor, is essential in Sertoli cells for germ cell differentiation via regulation of integrity of the blood–testis barrier (BTB) as well as Sertoli‐germ cell adhesion. Inactivation of Sox8… read more here.
Keywords: sox8 gene; chinese men; non obstructive; gene ... See more keywords
Clinical outcome of microsurgical vasoepididymostomy versus epididymal or testicular sperm retrieval combined with intracytoplasmic sperm injection in obstructive azoospermia males
Sign Up to like & getrecommendations! Published in 2022 at "Andrologia"
DOI: 10.1111/and.14458
Abstract: This purpose of the retrospective study was to compare the clinical outcome of microsurgical vasoepididymostomy (MVE) and sperm retrieval combined with intracytoplasmic sperm injection (ICSI) in the treatment of males with obstructive azoospermia. From February… read more here.
Keywords: microsurgical vasoepididymostomy; outcome microsurgical; clinical outcome; obstructive azoospermia ... See more keywords
The seminiferous tubule caliber pattern as evaluated at high magnification during microdissection testicular sperm extraction predicts sperm retrieval in patients with non‐obstructive azoospermia
Sign Up to like & getrecommendations! Published in 2019 at "Andrology"
DOI: 10.1111/andr.12548
Abstract: microTESE proved to be the gold standard surgical approach for patients with non‐obstructive azoospermia (NOA), but sperm retrieval rates (SRRs) vary considerably among centers. Some authors compared their SRRs with the pattern of seminiferous tubule… read more here.
Keywords: patients non; non obstructive; tubule caliber; seminiferous tubule ... See more keywords