Synthesis and Evaluation of Airway-Targeted PLGA-PEG Nanoparticles for Drug Delivery in Obstructive Lung Diseases.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0319-2_11
Abstract: Chronic airway inflammation is a hallmark of chronic obstructive airway diseases, including chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), and asthma. Airway inflammation and mucus obstruction present major challenges to drug or gene delivery… read more here.
Keywords: drug delivery; drug; obstructive lung; obstructive airway ... See more keywords
A prospective study of the impact of diabetes mellitus on restrictive and obstructive lung function impairment: The Saku study.
Sign Up to like & getrecommendations! Published in 2018 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2017.12.006
Abstract: BACKGROUND To assess the impact of diabetes on restrictive and obstructive lung function impairment. METHODS This 5-year prospective study included 7524 participants aged 40-69years without lung function impairment at baseline who underwent a comprehensive medical… read more here.
Keywords: obstructive lung; function impairment; lung function; lung ... See more keywords
Bronchodilator reversibility testing in post-COVID-19 patients undergoing pulmonary rehabilitation
Sign Up to like & getrecommendations! Published in 2021 at "Respiratory Medicine"
DOI: 10.1016/j.rmed.2021.106401
Abstract: Background The usefulness of bronchodilators in coronavirus diseases 2019 (COVID-19) survivors is still uncertain, especially for patients with a concomitant obstructive lung disease. We aimed at verifying the level of bronchodilator reversibility in COVID-19 patients… read more here.
Keywords: pulmonary rehabilitation; covid patients; concomitant obstructive; covid ... See more keywords
Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-26777-9
Abstract: Lung diseases, such as cystic fibrosis and COPD, are characterized by mucus obstruction and chronic airway inflammation, but their mechanistic link remains poorly understood. Here, we focus on the function of the mucostatic airway microenvironment… read more here.
Keywords: disease; obstructive lung; muco obstructive; epigenetic reprogramming ... See more keywords
Menopause, lung function and obstructive lung disease outcomes: a systematic review
Sign Up to like & getrecommendations! Published in 2018 at "Climacteric"
DOI: 10.1080/13697137.2017.1392504
Abstract: Abstract Background: The menopausal transition may have significant consequences for respiratory health, risk of chronic respiratory disease and management strategies. Objective: To systematically summarize the literature regarding the impact of menopause status on respiratory health… read more here.
Keywords: obstructive lung; lung function; menopause; disease ... See more keywords
Model-Based Estimation of Respiratory Parameters from Capnography, With Application to Diagnosing Obstructive Lung Disease
Sign Up to like & getrecommendations! Published in 2017 at "IEEE Transactions on Biomedical Engineering"
DOI: 10.1109/tbme.2017.2699972
Abstract: Objective: We use a single-alveolar-compartment model to describe the partial pressure of carbon dioxide in exhaled breath, as recorded in time-based capnography. Respiratory parameters are estimated using this model, and then related to the clinical… read more here.
Keywords: respiratory parameters; lung disease; disease; model ... See more keywords
Environmental pollutants damage airway epithelial cell cilia: Implications for the prevention of obstructive lung diseases
Sign Up to like & getrecommendations! Published in 2020 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.13323
Abstract: Mucociliary epithelium lining the upper and lower respiratory tract constitutes the first line of defense of the airway and lungs against inhaled pollutants and pathogens. The concerted beating of multiciliated cells drives mucociliary clearance. Abnormalities… read more here.
Keywords: environmental pollutants; function airway; obstructive lung; lung diseases ... See more keywords
Propensity Score Analysis of the Association between Chronic Obstructive Lung Disease and Stroke Outcome: Thailand's National Database.
Sign Up to like & getrecommendations! Published in 2022 at "Cerebrovascular diseases"
DOI: 10.1159/000521767
Abstract: INTRODUCTION The impact of coexisting chronic obstructive lung disease (COPD) in patients with stroke remains unclear. This study aims to investigate the effect of COPD on survival and hospital outcomes among stroke patients. METHODS The… read more here.
Keywords: propensity score; copd; disease; obstructive lung ... See more keywords
Comparison of the 2017 and 2015 Global Initiative for Chronic Obstructive Lung Disease Reports: Impact on Grouping and Outcomes
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.201707-1363oc
Abstract: Rationale: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) document has modified the grading system directing pharmacotherapy, but how this relates to the previous one from 2015 and to comorbidities, hospitalizations, and mortality risk… read more here.
Keywords: chronic obstructive; system; disease; initiative chronic ... See more keywords
Lack of Kcnn4 improves mucociliary clearance in muco-obstructive lung disease
Sign Up to like & getrecommendations! Published in 2020 at "JCI Insight"
DOI: 10.1172/jci.insight.140076
Abstract: Airway mucociliary clearance (MCC) is the main mechanism of lung defense keeping airways free of infection and mucus obstruction. Airway surface liquid volume, ciliary beating, and mucus are central for proper MCC and critically regulated… read more here.
Keywords: absorption; kcnn4; obstructive lung; muco obstructive ... See more keywords
Global Initiative for Chronic Obstructive Lung Disease (GOLD) 20th Anniversary: a brief history of time
Sign Up to like & getrecommendations! Published in 2017 at "European Respiratory Journal"
DOI: 10.1183/13993003.00671-2017
Abstract: The publication of the 2017 report of the Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease [2] marks the 20th anniversary of its birth back in 1997. The first Global… read more here.
Keywords: gold; chronic obstructive; obstructive lung; lung disease ... See more keywords