Biomarkers of obstructive nephropathy using a metabolomics approach in rat.
Sign Up to like & getrecommendations! Published in 2018 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2018.10.004
Abstract: Chronic kidney disease (CKD) has become a major public health problem worldwide and has a great impact on the quality of life of millions of people. Long-term obstructive uropathy is an important cause of CKD.… read more here.
Keywords: obstructive nephropathy; using metabolomics; metabolism; biomarkers obstructive ... See more keywords
GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy.
Sign Up to like & getrecommendations! Published in 2021 at "Cell death and differentiation"
DOI: 10.1038/s41418-021-00755-6
Abstract: Renal tubular cell (RTC) death and inflammation contribute to the progression of obstructive nephropathy, but its underlying mechanisms have not been fully elucidated. Here, we showed that Gasdermin E (GSDME) expression level and GSDME-N domain… read more here.
Keywords: inflammation fibrosis; gsdme mediated; obstructive nephropathy; gsdme ... See more keywords
Utility of urinary organic anion transporter 5 as an early biomarker of obstructive nephropathy
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13360
Abstract: Ureteral obstruction is a relevant cause of kidney damage. The traditional parameters used in clinical practice for the detection of renal injury are insensitive and non‐specific for the diagnosis of obstructive renal disease. The organic… read more here.
Keywords: ureteral obstruction; obstructive nephropathy; biomarker obstructive; biomarker ... See more keywords
Up‐regulation of the human‐specific CHRFAM7A gene protects against renal fibrosis in mice with obstructive nephropathy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17630
Abstract: Renal fibrosis is a major factor in the progression of chronic kidney diseases. Obstructive nephropathy is a common cause of renal fibrosis, which is also accompanied by inflammation. To explore the effect of human‐specific CHRFAM7A… read more here.
Keywords: obstructive nephropathy; renal fibrosis; chrfam7a; mice ... See more keywords
Alteration of N6-methyladenosine epitranscriptome profile in unilateral ureteral obstructive nephropathy.
Sign Up to like & getrecommendations! Published in 2020 at "Epigenomics"
DOI: 10.2217/epi-2020-0126
Abstract: Aim: To reveal the alterations of N6-methyladenosine (m6A) epitranscriptome profile in kidney after unilateral ureteral obstruction in mice. Materials & methods: Total renal m6A and expressions of methyltransferases and demethylases were detected by colorimetric quantification… read more here.
Keywords: unilateral ureteral; obstructive nephropathy; alteration methyladenosine; epitranscriptome profile ... See more keywords
Folic Acid Ameliorates Renal Injury in Experimental Obstructive Nephropathy: Role of Glycine N-Methyltransferase
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076859
Abstract: Folic acid exerts both anti-inflammatory and antifibrotic effects. Glycine N-methyltransferase (GNMT), the major folic acid-binding protein in the liver, is a crucial enzyme that regulates the cellular methylation process by maintaining S-adenosylmethionine levels. However, as… read more here.
Keywords: renal injury; folic acid; gnmt; obstructive nephropathy ... See more keywords